Manufacture of water-soluble β-hydroxynitriles

Details Manufacture of water-soluble β-hydroxynitriles Manufacture of water-soluble β-hydroxynitriles

2005-11-01

2005-11-01

Richter, Johann (Department: 1626)

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitriles

Reexamination Certificate

active

06960680

ABSTRACT:
A process for making a water-soluble β-hydroxynitrile. A 1,2-epoxide and an inorganic cyanide salt are reacted in a solvent having aqueous methanol and a buffer therein to form β-hydroxynitrile. The buffer substantially inhibits the formation of reaction products other than β-hydroxynitrile. Optionally, water may be removed from the β-hydroxynitrile by azeotropic distillation with acetonitrile and subsequently purified via vacuum distillation and filtration.

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