Manufacture of tocol, tocol derivatives and tocopherols

Details Manufacture of tocol, tocol derivatives and tocopherols Manufacture of tocol, tocol derivatives and tocopherols

2006-09-12

2006-09-12

Solola, Taofiq (Department: 1626)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C549S408000

Reexamination Certificate

active

07105686

ABSTRACT:
The present invention is concerned with a novel process for the manufacture of tocol, tocol derivatives and tocopherols, especially α-tocopherol, by the reaction of a hydroquinone featuring 0 to 3 methyl groups, especially 2,3,5-trimethylhydroquinone, with isophytol, phytol or a(n) (iso)phytol derivative, most preferably with isophytol, in the presence of gadolinium trifluoromethanesulfonate, Gd(OSO2CF3)3, as the catalyst in a biphasic solvent system. This biphasic solvent system consists essentially of a polar organic solvent and a non-polar organic solvent. The polar organic solvent is preferably ethylene carbonate and/or propylene carbonate. The non-polar solvent is preferably at least a solvent selected from the group consisting of hexane, heptane, octane, cyclohexane and methylcyclohexane.

REFERENCES:
patent: 658 552 (1995-06-01), None
patent: 694 541 (1996-01-01), None
patent: 694 541 (2000-03-01), None
patent: 1 180 517 (2002-02-01), None
Hamidi and Pascal, “Synthesis and Structural Characterization of Some Anhydrous Ln(OTf)3Complexes (Ln=Sc, La, Nd, Sm, Gd, and Er; OTf=CF3SO3),”Polyhedron, vol. 13, No. 11, pp. 1787-1792 (1994).
Schager and Bonrath, “Synthesis of D,L-α-tocopherol Using ‘Microencapsulated’ Catalysts,”Applied Catalysis A: General, vol. 202, pp. 117-120 (2000).
Schager and Bonrath, “Synthesis of D,L-α-tocopherol using Strong Solid Acids as Catalysts,”Journal of Catalysis, vol. 182, pp. 282-284 (1999).
Ullmann's Encyclopedia of Industrial Chemistry, vol. A27, 5thedition, pp. 484-485, VCH Verlagsgesellschaft mbH, Weinheim (1996).

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