Manufacture of polyglutamate-therapeutic agent conjugates

Details Manufacture of polyglutamate-therapeutic agent conjugates Manufacture of polyglutamate-therapeutic agent conjugates

2003-04-02

2008-07-15

Lukton, David (Department: 1654)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C514S279000, C514S283000, C530S345000, C562S575000

Reexamination Certificate

active

07399860

ABSTRACT:
The invention provides new processes for preparing polyglutamic acid-therapeutic agent conjugates for clinical development and pharmaceutical use, and polyglutamic acid-therapeutic agent conjugates prepared by these processes.

REFERENCES:
patent: 4356166 (1982-10-01), Peterson et al.
patent: 5629433 (1997-05-01), Zheng et al.
patent: 5892043 (1999-04-01), Tsujihara et al.
patent: 5977163 (1999-11-01), Li et al.
patent: 6441025 (2002-08-01), Li et al.
patent: 6617456 (2003-09-01), Tsujihara et al.
patent: WO 97/33552 (1997-09-01), None
patent: WO 99/49901 (1999-10-01), None
patent: WO 01/70275 (2001-09-01), None
Doonan, “Ch. 13 Bulk Purification by Fractional Precipitation,” Methods in Molecular Biology, 1996, pp. 135-144, vol. 59: Purification Protocols, Humana Press Inc., Totowa, New Jersey.
Richardson et al., “A New Biochemical Engineering Approach to the Fractional Precipitation of Proteins,” Biotechnology and Bioengineering, 1990, pp. 354-366, vol. 36, No. 4, John Wiley & Sons Inc.
Scopes, “Ch. 3, Separation by Precipitation,”Protein Purification, Principles and Practice,1982, pp. 39-66, Springer-Verlag, New York.
Scopes, “Ch. 5 Salting Out: Ammonium Sulfate Precipitation,”Proteins Labfax,1996, pp. 31-32, Academic, San Diego, CA.
Zimmerman et al., “The Precipitation of Poly-L-Glutamic Acid. I. α-Precipitation,”Biopolymers,1975, pp. 567-584, vol. 14, John Wiley & Sons Inc.
Zimmerman et al., “The Precipitation of Poly-L-Glutamic Acid. II. α -Precipitation,”Biopolymers,1975, pp. 585-596, vol. 14, John Wiley & Sons Inc.
Yoshinori Kato et al., “A Novel Method of Conjugation of Daunomycin with Antibody with a Poly-L-glutamic Acid Derivative as Intermediate Drug Carrier. An Anti-α-fetoprotein Antibody-Daunomycin Conjugate”, J. Med. Chem. 1984, 27, 1602-1607.
Conover et al., “Camptothecin Delivery Systems: Enhanced Efficacy and Tumor Accumulation of Camptothecin Following its Conjugation to Polyethylene Glycol via a Glycine Linker,”Cancer Chemother. Pharmacol.,1998, pp. 407-414, vol. 42, © Springer-Verlag.
de Vries et al., “Conjugation of Docetaxel (DTXL) to Poly L-Glutamic Acid (PG) Increases Anti-Tumor Efficacy,”Proceedings of the American Association for Cancer Research,Mar. 2000, p. 323, vol. 41.
Conover et al., “Camptothecin Delivery Systems: The Utility of Amino Acid Spacers for the Conjugation of Camptothecin with Polyethylene Glycol to Create Prodrugs,”Anti-Cancer Drug Design,1999, pp. 499-506, vol. 14, © Oxford University Press.
Duncan et al., “Polymer-Drug Conjugates, PDEPT and PELT:Basic Principles for Design and Transfer from the Laboratory to Clinic,”Journal of Controlled Release,2001, pp. 135-146, vol. 74, © 2001 Elsevier Science B.V.
Greenwald, “Camptothecin-20-PEG Ester Transport Forms:the Effect of Spacer Groups on Antitumor Activity”,Bioorganic&Medicinal Chemistry,1998, pp. 551-562, vol. 6, © 1998 Elsevier Science Ltd.
Li et al., “Complete Regression of Well-Established Tumors Using a Novel Water-Soluble Poly-(L-Glutamic Acid)-Paclitaxel Conjugate,”Cancer Research,Jun. 1, 1998, pp. 2404-2409, vol. 58.
Mathew, “Synthesis and Evaluation of Some Water-Soluable Prodrugs and Derivatives of Taxol with Antitumor Activity”,J. Med. Chem,1992, pp. 145-151, vol. 35, © American Chemical Society.
Singer et al., “Conjugation of Camptothecins to Poly-(L-Glutamic Acid),”Annals of New York Academy of Sciences,2000, pp. 136-150.
Zheng et al., “Deacetylation of Paclitaxel and Other Taxanes”,Tetrahedron Letters,1995, pp. 2001-2004, vol. 36, No. 12, © Elsevier Science Ltd.

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