Manufacture of partially fused peptide pellet

Details Manufacture of partially fused peptide pellet Manufacture of partially fused peptide pellet

1991-05-24

1992-08-11

Theisen, Mary Lynn

Plastic and nonmetallic article shaping or treating: processes

Forming articles by uniting randomly associated particles

Plural, intermittent pressure applying

264122, 424469, B29C 4302

Patent

active

051376695

ABSTRACT:
A bioerodible pellet capable of administering an even and continuous dose of a peptide over a period of up to a year, when subcutaneously implanted, is provided. The bioerodible implant is a partially-fused pellet, which pellet has a peptide drug homogeneously-bound in a matrix of a melted and recrystallized, nonpolymer carrier. Preferably, the nonpolymer carrier is a steroid and in particular is cholesterol or a cholesterol derivative. In one embodiment, the peptide drug is growth hormone-releasing hormone. A method for making the bioerodible pellet also is provided.

REFERENCES:
patent: 2987445 (1961-06-01), Levesque
patent: 3279998 (1966-10-01), Raff et al.
patent: 3800038 (1974-03-01), Rudel
patent: 4011061 (1977-03-01), Forseen et al.
patent: 4132753 (1979-01-01), Blichare et al.
patent: 4164560 (1979-08-01), Folkman et al.
patent: 4244949 (1981-01-01), Gupta
patent: 4369784 (1983-01-01), de Buman et al.
patent: 4452775 (1984-06-01), Kent
patent: 4526938 (1985-07-01), Churchill et al.
patent: 4591496 (1986-05-01), Cohen et al.
patent: 4601893 (1986-07-01), Cardinal
patent: 4667014 (1987-05-01), Nestor, Jr. et al.
patent: 4720384 (1988-01-01), Di Luccio et al.
patent: 4748024 (1988-05-01), Leonard
patent: 4774091 (1988-09-01), Yamahira et al.
patent: 4801577 (1989-01-01), Nestor, Jr. et al.
patent: 4803076 (1989-02-01), Ranade
patent: 4806337 (1989-02-01), Snipes et al.
patent: 4814182 (1989-03-01), Graham et al.
patent: 4863736 (1989-09-01), Azain et al.
patent: 4892734 (1990-01-01), Leonard
patent: 4894231 (1990-01-01), Moreau et al.
patent: 5019302 (1991-05-01), Sparks et al.
J. Heller, "Bioerodible Systems", (pp. 69-101) Chapter 3 in Medical Application of Controlled Release.

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