Manufacture of optically active 2-phenylpropionic acid and 2-phe

Details Manufacture of optically active 2-phenylpropionic acid and 2-phe Manufacture of optically active 2-phenylpropionic acid and 2-phe

1992-03-12

1993-11-02

Robinson, Douglas W.

Chemistry: molecular biology and microbiology

Process of utilizing an enzyme or micro-organism to destroy...

Resolution of optical isomers or purification of organic...

435129, 435136, 435843, C12P 1302, C12P 740, C12P 4100

Patent

active

052583058

ABSTRACT:
The present invention provides a method of obtaining optically active 2-phenylpropionic acid and 2-phenylpropionamide such as S-(+)-2-phenylpropionic acid, R-(-)-2-phenylpropionamide, and R-(-)-2-phenylpropionic acid from S-2-phenylpropionitrile or R,S-2-phenylpropionamide using a bacterium belonging to Rhodococcus equi.
Optically active 2-phenylpropionic acid and 2-phenylpropionamide are recovered in high yield and in quantities according to the method of the invention.

REFERENCES:
patent: 5034329 (1991-07-01), Cerbelaud et al.
patent: 5089405 (1992-02-01), Cerbelaud et al.
Yamamoto K, Appl. Environ. Micro. 56:3125-29 (1990).
ATCC Catalog pp. 64, 184-188 (1989).
Gilligan et al., 1991, Production of R(-) and S(+)-2Phenylpropionic Acid Using Nitrile Hydrolyzing Bacteria, Abstract No. 3G2p1, Nippon Nogeikagaku Kai 1991 Mar. 3, 1965-Japan Society for Bioscience, Biotechnology and Agrochemistry and copy of slides and verbal presentation.

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