Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...
Patent
1978-04-06
1981-01-13
Jiles, Henry R.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Bacterium or component thereof or substance produced by said...
A61K 3156
Patent
active
042449499
ABSTRACT:
This invention relates to a bioabsorbable fused implant for subcutaneous administration in mammals of a constant and effective amount of a steroid over a prolonged period comprising a solid dispersion of an effective amount of a steriod uniformly dispersed in a matrix of a lipoid carrier the weight of steroid to lipoid carrier being within the approximate range of 99:1 to 80:20, respectively, and to the method of manufacturing the fused implants.
REFERENCES:
Shimkin and White, Absorption Rate of Hormone-Cholesterol Pellets, Endrocrinology, 29:1020, 1941.
P. M. F. Bishop, et al, Absorption of Hormone Implants in Man, Lancet, Aug. 11, 1951, pp. 229-232.
Lipschutz, et al., Recovery of Fertility After Protracted Steroid-Induced Sterility in Mice, Nature, vol. 190, pp. 174-175 (1961).
Jiles Henry R.
The Population Council, Inc.
Whittenbaugh Robert C.
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