Manufacture of interferon

Details Manufacture of interferon Manufacture of interferon

1975-01-07

1976-04-20

Tanenholtz, Alvin E.

Textiles: fiber preparation

195 29, C12D 1302

Patent

active

039517403

ABSTRACT:
This invention relates to the production of interferon. In accordance with the present invention, interferon is produced by growing a continuous cell line in a suspension culture, the cells first being primed by cultivation in the presence of interferon specific to the cells and L-glutamine, interferon production being initiated by contacting the cells with a high concentrated suspension of virus inducer, then removing the virus and incubating the cells in a nutrient medium. Concentration and purification to give interferon preparations can be effected by known methods. Various types of interferon preparations of high titre have been produced on an industrial scale.

REFERENCES:
patent: 3548053 (1970-12-01), Joshi et al.
patent: 3773924 (1973-11-01), Ho et al.
Nature Vol. 182 pp. 1075-1074 (1958).
J. Gen. Virol. Vol. 15 (Pt. 2) pp. 119-128 (1972).
J. Gen. Virol. Vol. 17, pp. 107-109 (1972).

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