Manufacture of haloalkyl lactams

Details Manufacture of haloalkyl lactams Manufacture of haloalkyl lactams

1987-03-20

1988-12-20

Springer, David B.

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

546243, 548547, C07D207263, C07D21176, C07D22310

Patent

active

047926040

ABSTRACT:
A process for the manufacture of haloalkyl lactams having the formula ##STR1## wherein n is an integer having a value of from 1 to 3; m is an integer having a value of 1 or 2 and X is chlorine or bromine in the absence of an inert solvent by reacting a hydroxyalkyl lactam of the formula ##STR2## with a thionyl chloride or bromide in the liquid phase under anhydrous conditions, vaporizing and removing any excess thionyl halide along with SO.sub.2 by-product from the liquid reaction mixture under vacuum followed by vacuum distillation of the remaining liquid product mixture at a temperature below its decomposition and recovering said product.
The product of this process can be obtained in greater than 90% yield and 99% purity.

REFERENCES:
patent: 2555354 (1951-06-01), Lucas et al.
patent: 4202821 (1980-05-01), Scheider et al.

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