Manufacture of diethylaminoethyl dextrans

Details Manufacture of diethylaminoethyl dextrans Manufacture of diethylaminoethyl dextrans

1983-06-14

1985-03-26

Phillips, Delbert R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536112, C08B 3702

Patent

active

045074720

ABSTRACT:
This invention relates to an improved process for the manufacture of diethylaminoethyl dextran (DEAE dextran) and the diethylaminoethyl derivative of hydrogenated dextran (DEAE hydrodextran). A product of greater purity and improved color is obtained by the addition of a borohydride, such as sodium borohydride during manufacture to generate hydrogen in situ during the reaction.

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Platoshkin, B-Aminoethyldextran, Chem. Abstracts 82: 74774v, (1974).
Tryon et al., Hydrodextran: Preparation and Study on Blood Level and Excretion Rate, Chem. Abstracts 48: 3553h, (1954).
McKernan et al., A Basic Derivative of Dextran and Its Interaction with Biological Systems, Chemistry and Industry, pp. 1490-1491, (Nov. 1959).
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