Manufacture of arrays with reduced error impact

Details Manufacture of arrays with reduced error impact Manufacture of arrays with reduced error impact

2005-09-06

2005-09-06

Goldberg, Jeanine A. (Department: 1634)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

C435S091100, C435S091200, C435S287200, C536S023100, C536S024300

Reexamination Certificate

active

06939673

ABSTRACT:
Methods and apparatus are disclosed for synthesizing a purality of compounds such as biopolymers on the surface of supports. The synthesis comprises a plurality of steps in which reagents for conducting the synthesis are deposited o the surface of the support to form precursors of the chemical compounds and, ultimately, the chemical compounds themselves. An error in the deposition may occur in one or more of the plurality of steps. A reagent for forming the chemical compounds is deposited on the surface of the support. A determination is made as to whether an error occurred in the depositing of the reagent. If an error is detected, the support is treated to re-deposit at least some of those reagents that were not correctly deposited. In one approach the support is treated to stabilize precursors of the chemical compounds, the source of the error is corrected, and the reagent applied above is re-deposited on the surface.

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U.S. Appl. No. 09/302,898, filed Apr. 30, 1999, Caren et al.
U.S. Appl. No. 09/359,527, filed Jul. 22, 1999, Web et al.

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