Manufacture of alpha-arylalkanoic acids and precursors

Details Manufacture of alpha-arylalkanoic acids and precursors Manufacture of alpha-arylalkanoic acids and precursors

1985-06-05

1987-03-31

Killos, Paul J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

568591, 560 56, 562466, 562490, 260456R, C07C 6976, C07C 53134

Patent

active

046544380

ABSTRACT:
.alpha.-Arylalkanoic acids or esters, orthoesters or amides thereof are prepared by forming an .alpha.-hydroxy ketal or thioketal of an aryl alkyl ketone, activating the .alpha.-hydroxy substituent with an esterifying agent to form the corresponding ketal or thioketal ester substrate, wherein the ester group is sufficiently labile to non-catalytically disassociate from the substrate in a protic or dipolar, aprotic solvent, maintaining the ester substrate in contact with the protic or dipolar, aprotic solvent or mixtures thereof for a time sufficient to form the corresponding .alpha.-arylakanoic acid or ester, orthoester or amide thereof, and optionally concomitantly or sequentially hydrolyzing any ester, orthoester or amide formed to the corresponding .alpha.-arylalkanoic acid.

REFERENCES:
patent: 4539420 (1985-09-01), Tsuchihashi et al.

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