Manufacture of alpha-arylalkanoic acids and precursors

Details Manufacture of alpha-arylalkanoic acids and precursors Manufacture of alpha-arylalkanoic acids and precursors

1983-06-07

1985-09-17

Killos, Paul J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

562469, 562496, 560 56, 560 59, 560100, 560105, 564161, 564171, 564182, 568308, 568328, 568335, 568336, 568442, 568592, 568593, 568630, 260686, C07C 6336, C07C 6976

Patent

active

045422370

ABSTRACT:
.alpha.-Arylalkanoic acids or esters, orthoesters or amides thereof are prepared by forming an .alpha.-hydroxy ketal or thioketal of an aryl alkyl ketone, activating the .alpha.-hydroxy substituent with an esterifying agent to form the corresponding ketal or thioketal ester substrate, wherein the ester group is sufficiently labile to non-catalytically disassociate from the substrate in a protic or dipolar, aprotic solvent, maintaining the ester substrate in contact with the protic or dipolar, aprotic solvent or mixtures thereof for a time sufficient to form the corresponding .alpha.-arylakanoic acid or ester, orthoester or amide thereof, and optionally concomitantly or sequentially hydrolyzing any ester, orthoester or amide formed to the corresponding .alpha.-arylalkanoic acid.

REFERENCES:
patent: 4263443 (1981-04-01), White
patent: 4268442 (1981-05-01), Kondo et al.

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