Manufacture of 2-cyano-propionate esters

Details Manufacture of 2-cyano-propionate esters Manufacture of 2-cyano-propionate esters

1975-03-13

1976-05-11

Brust, Joseph P.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260464, C07C12000

Patent

active

039563570

ABSTRACT:
A process for the manufacture of 2-cyano-propionate esters which comprises hydrogenating in the presence of an hydrogenating catalyst a mixture of a cyano-acetic ester, formaldehyde and a condensation catalyst. Typically ethyl cyano-acetate is treated with formalin or paraform and hydrogen in the presence of palladium on carbon and zinc acetate. Preferably an antioxidant or polymerisation inhibitor is also included in the reaction mixture which also usually includes solvents such as glacial acetic acid or toluene.

REFERENCES:
patent: 3173939 (1965-03-01), Johnson
patent: 3350439 (1967-10-01), Feldman et al.
migrdichian; The Chemistry of Organic Cyanogen Compounds: 1947; pp. 319 and 323; Reinhold Pub. Corp.
House; Modern Synthetic Reactions; 2nd ed., 1972; pp. 646-647; Benjamin, Inc.
Alexander, et al; J.A.C.S.; 66; pp. 886-888.

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