Manufacture and purification of mycophenolic acid

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing heterocyclic carbon compound having only o – n – s,...

Reexamination Certificate

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C435S123000

Reexamination Certificate

active

06927047

ABSTRACT:
The present invention provides an improved method for the manufacture of Mycophenolic acid by solid substrate fermentation ofPencillium brevi-campactum, in a contained bioreactor under optimal fermentation parameters with its subsequent purification steps.

REFERENCES:
patent: 4452891 (1984-06-01), Kida et al.
patent: WO00/29544 (2000-05-01), None
patent: WO 00/29544 (2000-05-01), None
Abs JP359091891A Ozaki et al May 26, 1984.
Muth, W.L. et al. “Biosynthesis of mycophenolic acid: purification and characterization of S-adenosyl-L-methionine: demethylmycophenolic acid O-methyltransferase.” Antimicrob. Agents and Chemother. (1975), 8(3), pp. 321-327 (abstract only).
Sudhukhan, A.K. et al. “Optimization of mycophenolic acid production in solid state fermentation using rsponse surface methodology.” Journal of Industrial Microbiology & Biotechnology (1999) 22, pp. 33-38.
B. Gosivo, Riv. Igiene Sanita Pub. Ann, 7, 825-869, 1896.
Muth and Nash, Antimicrobial Agents and Chemotherapy, 8, 321-327, 1896.
Sadhukhan et al. J. Ind. Microbiol, Biotechnol.22, 33-38, 1999.

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