Manufacture and expression of genes for urogastrone and polypept

Details Manufacture and expression of genes for urogastrone and polypept Manufacture and expression of genes for urogastrone and polypept

1985-05-07

1988-08-16

Foelak, Morton

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

25 or more amino acid residues in defined sequence

530350, 530399, 530820, 530825, 530834, 435 68, 435 70, C07K 700

Patent

active

047645938

ABSTRACT:
Disclosed are DNA sequences comprising structural genes coding for (1) a polypeptide having the amino acid sequence and properties of urogastrone and for (2) polypeptide analogs thereof which differ in terms of the identity and/or location of one or more amino acids, e.g., [Asp.sup.25 ] and Pro.sup.52, Pro.sup.53 ] analogs of urogastrone. Structural gene sequences may be provided with initial and terminal sequences which facilitate production of discrete protein products by selected host microorganisms as well as for expression by host organisms of fusion proteins, e.g., .beta.-lactamase-urogastrone and .beta.-galactosidase-urogastrone from which the desired products may be isolated.

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