Manoalide analogs

Details Manoalide analogs Manoalide analogs

1986-02-19

1988-12-06

Milestone, Norma S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549318, 514825, 514885, 514886, C07D40704, C07D30760

Patent

active

047897490

ABSTRACT:
Analogs of the marine natural product manoalide are useful in treating mammals, including humans, in need of a drug having analgesic/anti-inflammatory, immunosuppressive, and/or antiproliferative activity.

REFERENCES:
patent: 4447445 (1984-05-01), Jacobs et al.
patent: 4616089 (1986-10-01), Jacobs et al.
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S. Katsumura et al, Tetrahedron Letters, vol. 26 (47), (1985), pp. 5827-5830.
F. W. Sum et al, Tetrahedron, vol. 37, Supplement No. 1, (1981), pp. 303-317.
S. Takahashi, Synthetic Communications, vol. 6 (5), (1976), pp. 331-337.
E. deSilva et al, "Manoalide, an Antibiotic Sesterterpenoid from the Marine Sponge Luffariella Variabilis (Polejaeff)", Tett. Let. 21: 1611-1614, (1980).
E. deSilva et al, "Three New Sesterterpenoid Antibiotics from the Marine Sponge Luffariella Variabilis (Polejaff)", Tett. Let., (1981), 3147-3150.

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