Mannose binding lectin knock-out mice and methods of use...

Multicellular living organisms and unmodified parts thereof and – Nonhuman animal – Transgenic nonhuman animal

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C800S008000, C800S025000

Reexamination Certificate

active

07491868

ABSTRACT:
A transgenic non-human animal with alterations in the MBL gene is prepared by introduction of a gene encoding an altered MBL protein into a host non-human animal. Methods for using transgenic mice so generated to screen for agents that effect MBL's cellular modulating activity are also provided.

REFERENCES:
patent: 2004/0043034 (2004-03-01), Jensenius et al.
Moreadith et al., Gene targeting in embryonic stem cells: the new physiology and metabolism. J Mol Med. 75(3):208-16, 1997.
Leonard et al., Role of the common cytokine receptor gamma chain in cytokine signaling and lymphoid development. Immunol Rev. 148:97-114, 1995.
Griffiths et al., Current concepts of PLP and its role in the nervous system. Microsc Res Tech. 41(5):344-58, 1998.
Chu et al., Repeated respiratory Mycoplasma pneumoniae infections in mice: effect of host genetic background, Microbes Infect. 8(7):1764-72, 2006.
Sastry et al., Characterization of murine mannose-binding protein genes Mbl1 and Mbl2 reveals features common to other collectin genes, Mamm Genome. 6(2):103-10, 1995.
Kuhlman, Marcella, et al. “The human mannose-binding protein functions as an opsonin.” Journal of Experimental Medicine, vol. 169. 1989. pp. 1733-1745.
Sastry, Kedarnath, et al. “Molecular Characterization of the Mouse Mannose-Binding Proteins: The mannose-binding protein A but not C is an acute phase reactant.” Journal of Immunology, vol. 147, No. 2, 1991. pp. 692-697.
Sheriff, Steven, et al. “Human Mannose-Binding Protein Carbohydrate Recognition Doman Trimerizes Through a Triple Alpha-Helical Coiled Coil.” Structural Biology, vol. 1, No. 11. Nature Publishing Group. 1994. pp. 789-794.
Thiel, Steffan, et al. “A Second Serine Protease Associated with Mannan-Binding Lectin That Activates Complement.” Nature, vol. 386. Apr. 3, 1997. pp. 506-510.
Dahl, Mads, et al. MASP-3 and its Association with Distinct Complexes of the Mannan-Binding Lectin Complement Activation Pathway. Immunity, vol. 15. Jul. 2001. pp. 127-135.
Liu, H., et al. “Characterization and Quantification of Mouse Mannan-Binding Lection (MBL-A and MBL-C) and Study of Acute Phase Responses.” Scandanavian Journal of Immunology, vol. 53. Jan. 19, 2001. pp. 489-497.
Neth, Olaf, et al. “Deficiency of Mannose-Binding Lectin and Burden of Infection in Children with Malignancy: A Prospective Study.” The Lancet, vol. 358. Aug. 25, 2001. pp. 614-618.
Peterslund, Niels A., et al. “Associated Between Deficiency of Mannose-Binding Lectin and Severe Infections After Chemotherapy.” The Lancet, vol. 358. Aug. 25, 2001. pp. 637-638.
Mulligan, Charles G., et al. “Mannose-Binding Lectin Gene Polumorphisms Are Associated With Major Infection Following Allogenic Hemopoietic Stem Cell Transplantation.” Blood, vol. 99, No. 10. May 15, 2002. pp. 3524-3529.
Neth, Olaf, et al. “Enhancement of Complement Activation and Opsonophagosytosis by Complexes of Mannose-Binding Lectin with Mannose-Binding Lectin-Associated Serine Protease After Binding toStaphylococcus aureus.” Journal of Immunology, vol. 169. 2002. pp. 4430-4436.
Takahashi, Kazue. “Lack of Mannose-Binding Lectin-A Enhances Survival in a Mouse Model of Acute Septic Peritonitis.” Microbes and Infection, vol. 4. 2002. pp. 773-784.
Gadjeva, M., et al. “Mannan-Binding Lectin Modulates the Response to HSV-2 Infection.” Clin. Exp. Immunology, vol. 138. 2004. pp. 304-311.
Shi, Lei, et al. “Mannose-Binding Lectin-Deficient Mice Are Susceptible to Infection withStaphylococcus aureus.” Journal of Experimental Medicine, vol. 199, No. 10. Rockefellar University Press. May 17, 2004. pp. 1379-1390.
Takahashi, Kazue, et al. “Mannose-Binding Lectin Modulates Thymus-Dependent Antigen Responses.” Molecular Immunology, vol. 41. 2004. pp. 201-333 (Conference Abstract).
Hart, Melanie L., et al. “Gastrointestinal Ischemia-Reperfusion Injury is Lectin Complement Pathway Dependent Without Involving C1q.” Journal of Immunology, vol. 174. pp. 6373-6380.
Moller-Kristensen, M., et al. “Mannan-Binding Lectin Recognizes Structures on Ischaemic Reperfused Mouse Kidneys and is Implicated in Tissue Injury.” Scandanavian Journal of Immunology, vol. 61. 2005. pp. 426-434.
Walsh, Mary C., et al. “Mannose-Binding Lectin is a Regulator of Inflammation That Accompanies Myocardial Ischemia and Reperfusion Injury.” Journal of Immunology, vol. 175. 2005. pp. 541-546.
McMullen, Megan E., et al. “Mannose-Binding Lectin Binds IgM to Activate the Lectin Complement Pathway In Vitro and In Vivo.” Immunobiology, vol. 211. 2006. pp. 759-766.
Moller-Kristensen, Mette, et al. “Deficiency of Mannose-Binding Lectin Greatly Increases Susceptibility to Postburn Infection with Pseudomonas Aeruginosa.” Journal of Immunology, vol. 176. 2006. pp. 1769-1775.
Zhang, Ming, et al. “Activation of the Lectin Pathway by Natural IgM in a Model of Ischemia-Reperfusion Injury.” Journal of Immunology, vol. 177. 2006. pp. 4727-4734.
Takahashi, “Mannose Binding Protein a Null Mice Display Enhanced Survival in an Acute Septic Peritonitis Model,” Soc. Leuk. Biol., 34th Ann. Meeting, MA, Oct. 5-8, 2000.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Mannose binding lectin knock-out mice and methods of use... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Mannose binding lectin knock-out mice and methods of use..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Mannose binding lectin knock-out mice and methods of use... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-4088136

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.