Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Reduced antigenicity – reduced ability to bind complement – or...
Patent
1982-01-21
1983-08-09
Rosen, Sam
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Reduced antigenicity, reduced ability to bind complement, or...
260112R, 435240, 435241, A61K 3700
Patent
active
043978436
ABSTRACT:
A new reagent effective in inhibiting cholesterol synthesis 75% in human fibroblasts derived from patients suffering from the disease familial hypercholestrolemia is Man6P-low density lipoprotein and is effective in tissue culture test systems at 100 .mu.g/ml after a ten-hour exposure. The broad purpose of this invention is to modify the receptor specificity of a protein so that it will enter cells which were previously impermeable and exert new effects or reverse a pathological condition. That is, the compound of this invention is a useful reagent in the selective cytotoxic treatment of hypercholesterolemia.
REFERENCES:
onin et al.-Chem. Abst., vol. 89, (1978), p. 1790g.
Murray Gary J.
Neville Jr. David M.
Youle Richard J.
Roberts, Jr. John S.
Rosen Sam
The United States of America as represented by the Department of
LandOfFree
Mannose-6-phosphate-low density protein reagent effective agains does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Mannose-6-phosphate-low density protein reagent effective agains, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Mannose-6-phosphate-low density protein reagent effective agains will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-586812