Mannose-6-phosphate composition and its use in treating fibrotic

Details Mannose-6-phosphate composition and its use in treating fibrotic Mannose-6-phosphate composition and its use in treating fibrotic

1999-02-03

2000-07-25

Azpuru, Carlos A.

Drug, bio-affecting and body treating compositions

Topical body preparation containing solid synthetic organic...

Ophthalmic preparation

424443, A61K 3174, A61F 1300

Patent

active

060933887

ABSTRACT:
Mannose-6-phosphate is formulated by pH adjustment as a suspension or solution at pH 6 to 8, preferably 6.5 to 7.5 and preferably at a concentration of 65 to 300 mM. Suspensions can be made in viscous hyaluronic acid gels. These compositions are useful in wound healing, particularly to prevent or mitigate scar formation.

REFERENCES:
patent: 5244651 (1993-09-01), Kayane et al.
patent: 5520926 (1996-05-01), Ferguson
H.U. Bergmeyer Editor, "Methods of Enzymatic Analysis", Verlag Chemie, Weinheim vol. II, 292, (1993).
I. Sato et al., "Depolymerization of Hyaluronic Acid by D-Fructose 6-Phosphate", Biosci. Biotech. Biochem., 57(12), 2005-2009 (1993).
A. Waheed et al., "Quarternary Structure of the M.sub.r 46000 Mannose 6-Phosphate Specific Receptor: Effect of Ligand,, pH, and Receptor Concentration on the Equilibrium between Dimeric and Tetrameric Receptor Forms", Biochemistry 29 No. 10, 2449-2455 (1990).

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