Mannobiose derivatives

Details Mannobiose derivatives Mannobiose derivatives

1988-03-31

1991-01-08

Griffin, Ronald W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 182, 536 22, 536 53, C07H 304, C07H 504

Patent

active

049837257

ABSTRACT:
Novel mannobiose derivative represented by the general formula [I]: ##STR1## wherein groups of R.sub.1 to R.sub.5 each represents --OH, --OR.sub.6, --NHR.sub.6, (R.sub.6 represents an acyl group) or a group represented by the following formula (a), (b), (c), (d) or (e), provided that one of R.sub.1 to R.sub.5 represents --OR.sub.6 or --NHR.sub.6, one of the other 4 groups of R.sub.1 to R.sub.5 represents one of the groups represented by the formulae (a) to (e), and the remaining 3 groups of R.sub.1 to R.sub.5 represent --OH: ##STR2## wherein represents .alpha. or .beta. bond are provided by the invention.
These compounds give liposomes a specific affinity for Kupffer cells of liver, and can be produced industrially.

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Wu et al; Biochim. Biophys. Acta, 675:19-29 (1981).
Szoka, Jr. et al; Biochem. Biophys. Res. Commun., 110(1):140-146 (1983).
Ogawa et al; Carb. Res., 104:271-283 (1982).

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