Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1999-01-28
2000-01-25
Huang, Evelyn Mei
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
546217, 546221, A61K 31445, C07D21148
Patent
active
060179333
ABSTRACT:
Mannich bases of conjugated styryl ketones have been developed which are effective as cytotoxicity and anticancer agents, and which also have antifungal activity. Preferred compounds are those of the formula ##STR1## where R.sub.1 is Cl, CH.sub.3 or OCH.sub.3 and R.sub.2 is H or Cl. A compound of particular interest is (3-[3-(4-chlorophenyl)-2-propenoyl]-4-[2-(4-chlorophenyl)vinylene]-1-ethyl -4-piperidinol hydrochloride.
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Elias K. Manavathu et al., "In vitro antifungal activity of some Mannich bases of conjugated styryl ketones," Can. J. Microbiol. 44: 74-79 (1998).
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B. V. Unkovskii et al., "Steric Structure of 1-alkyl-3-benzoyl-4-piperidinols and the stereochemistry of their synthesis," M. V. Lomonosov Moscow Institute of Fine Chemical Technology, pp. 1483-1487. Translated from Zhurnal Organicheskoi Khimii, vol. 2, No. 8, pp. 1501-1507, Aug., 1966.
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SciFinder, Oct. 9, 1997, Answers 1-21, pp. 1-10.
Dimmock Jonathan R.
Manavathu Elias K.
Huang Evelyn Mei
University of Saskatchewan Technologies Inc.
Wayne State University
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