Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1989-10-06
1994-02-22
Cashion, Jr., Merrell C.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
530327, 530328, A61K 3702, C07K 706
Patent
active
052887057
ABSTRACT:
Administration into fish of gonadotropin releasing hormone (GnRH), luteinising releasing hormone (LHRH) and their analogs in a polymer based sustained release delivery system was found to induce a prolonged elevation in the fish's plasma level of gonadotropin (GtH), which leads to ovulation and spawning. Such induction of ovulation and spawning was found to occur both within the natural spawning season and outside this season. Such administration thus enables for the first time an effective means for manipulating reproduction in fish, which is a very important factor in the economic management of fish farming.
REFERENCES:
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patent: 4410514 (1983-10-01), Vale, Jr. et al.
patent: 4443368 (1984-04-01), Sherwood et al.
patent: 4647552 (1987-03-01), Gulyas et al.
patent: 4659693 (1987-04-01), Nestor
Chemical Abstracts Accession No. 110(12):101646; Sherwood et al., "Sustained hormone release, I, Characteristics of in vitro release of gonadotropinreleasing hormone analog (GnRH-A) from pellets" & Aquaculture, 74(1-2), 75-86.
Chemical Abstracts Accession No. 107(13): 109765; Fraser et al., "An implant of a Gonadotropin release hormone agonist (buserelin) which suppresses ovarian function in the macaque for 3-5 months", & Acta Endocrinol, (Copenhagen), 115(4) 521-527.
Cashion Jr. Merrell C.
Israel Oceanographic & Limnological Research Ltd.
Marshall S. G.
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