Drug – bio-affecting and body treating compositions – Whole live micro-organism – cell – or virus containing
Patent
1998-07-10
2000-11-21
Guzo, David
Drug, bio-affecting and body treating compositions
Whole live micro-organism, cell, or virus containing
424 9321, 424 932, 435375, 435325, 4353201, 435 691, 435 701, 435 914, 435 721, 514 44, C12W 506, C12W 508, A01N 4800
Patent
active
061499021
ABSTRACT:
The present invention is directed to methods for the expansion of non-terminally differentiated cells ("precursor cells") using agonists of Notch function, by inhibiting the differentiation of the cells without inhibiting proliferation (mitotic activity) such that an expanded population of non-terminally differentiated cells is obtained. The cells are preferably stem or progenitor cells. These expanded cells can be used in cell replacement therapy to provide desired cell populations and help in the regeneration of diseased and/or injured tissues. The expanded cell populations can also be made recombinant and used for gene therapy, or can be used to supply functions associated with a particular precursor cell or its progeny cell.
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Artavanis-Tsakonas Spyridon
Fortini Mark Edward
Matsuno Kenji
Guzo David
Shuman Jon
Yale University
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