Manipulation of neuronal ion channels

Details Manipulation of neuronal ion channels Manipulation of neuronal ion channels

2004-01-21

2009-12-08

Chong, Kimberly (Department: 1635)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

C536S024310, C536S024500, C536S024100

Reexamination Certificate

active

07629323

ABSTRACT:
The present invention provides compositions and methods for the manipulation of ion channels. For example, the present invention relates to Parkinson's and other neurological diseases and conditions, and treatments thereof. In particular, the present invention provides methods of decreasing pathophysiological high frequency neuronal bursts of Parkinson's and other neurological diseases and conditions. Methods of the present invention comprise decreasing Kv3 ion channel activity in fast-spiking neurons, including by decreasing activity of a Kv3.4 protein and by specifically targeting a Kv3.4 protein with an inhibitor.

REFERENCES:
patent: 6071891 (2000-06-01), Low et al.
patent: WO 02/44321 (2002-06-01), None
Paroo et al. Challenges for RNAi in vivo. Trends in Biotechnology (2004), vol. 22(8) 390-394. Elsevier.
Caplen NJ. RNAi as a Gene Therapy Approach. Expert Opinon. Biol. Thera. (2003) vol. 3(4) 575-586. Ashley Publications Ltd.
Adams, A. RNA therapeutics enter clinical trials. Scientist (2005), vol. 19:Issue 1. Institute for Scientific Information.
Green et al. Antisense oligonucleotides: an evolving technology for the modulation of gene expression in human disease. J Am Coll Surg (2000), vol. 191: 93-105. Elsevier.
Jen et al. Suppresion of Gene Expression by Targeted Disruption of Messenger RNA: Available Options and Current Strategies. Stem Cells (2000), vol. 18:307-319. AlphaMed Press.
Novina et al. The RNAi Revolultion. Nature 2004, vol. 430: 161-164. Nature Publishing Group.
Hammond et al. Post-transcriptional gene silencing by double-stranded RNA Nature Reviews, 2001, vol. 2, 110-119. MacMillan Magazines Ltd.
Chang et al. The increase of voltage-gated potassium channel Kv3.4 mRNA expression in oral squamous cell carcinoma. J Oral Pathol Med. 2003, vol. 32: 606-11.
Tkatch et al. Kv3.4 KChannels may be responsible for spike broadening during burst firing in Globus Pallidus neurons. Society for Neuroscience, 1999, vol. 25: 179.17.
Rudy, B. & McBain, C. J. TINS 24, 517-26 (2001).
Coetzee, W. A. et al., Ann N Y Acad Sci 868, 233-85 (1999).
Brew, H. M. & Forsythe, I. D. J Neurosci 15, 8011-22 (1995).
Du, J., Zhang, L., Weiser, M., Rudy, B. & McBain, C. J., Neurosci 16, 506-18 (1996).
Lenz, S., Perney, T. M., Qin, Y., Robbins, E. & Chesselet, M. F., Synapse 18, 55-66 (1994).
Weiser, M. et al., J Neurosci 14, 949-72 (1994).
Weiser, M. et al., J Neurosci 15, 4298-314 (1995).
Martina, M., Schultz, J. H., Ehmke, H., Monyer, H. & Jonas, P., J Neurosci 18, 8111-25 (1998).
Baranauskas, G., Tkatch, T. & Surmeier, D. J.. J Neurosci 19, 6394-404 (1999).
Erisir, A., Lau, D., Rudy, B. & Leonard, C. S., J Neurophysiol 82, 2476-89 (1999).
Wigmore, M. A. & Lacey, M. G., J Physiol 527 Pt 3, 493-506 (2000).
Schroter, K. H. et al., FEBS Lett 278, 211-6 (1991).
Rettig, J. et al., Embo J 11, 2473-86 (1992).
Diochot, S., Schweitz, H., Beress, L. & Lazdunski, M., J Biol Chem 273, 6744-9 (1998).
Thompson, S., J Gen Physiol 80, 1-18 (1982).
Song, W. J. et al., J Neurosci 18, 3124-37 (1998).
Kofuji, P., Davidson, N. & Lester, H. A., Proc Natl Acad Sci U S A 92, 6542-6 (1995).
Sheng, M., Liao, Y. J., Jan, Y. N. & Jan, L. Y., Nature 365, 72-5 (1993).
Wang, H. S. et al., Science 282, 1890-3 (1998).
Abbott, G. W. et al., Cell 104, 217-31 (2001).
Macica, C. M. & Kaczmarek, L. K., J Neurosci 21, 1160-8 (2001).
Murakoshi, H., Shi, G., Scannevin, R. H. & Trimmer, J. S., Mol Pharmacol 52, 821-8 (1997).
Rettig, J. et al., Nature 369, 289-94 (1994).
Surmeier, D. J., Bargas, J., Hemmings, H. C., Jr., Nairn, A. C. & Greengard, P., Neuron 14, 385-97 (1995).
Hamill, O. P., Marty, A., Neher, E., Sakmann, B. & Sigworth, F. J., Pflugers Arch 391, 85-100 (1981).
Yan, Z. & Surmeier, D. J., J Neurosci 16, 2592-604 (1996).
Tkatch, T., Baranauskas, G. & Surmeier, D. J., Neuroreport 9, 1935-9 (1998).
Rhodes, K. J. et al., J Neurosci 17, 8246-58 (1997).

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