Organic compounds -- part of the class 532-570 series – Organic compounds
Reexamination Certificate
2006-12-05
2006-12-05
Campell, Bruce R. (Department: 1648)
Organic compounds -- part of the class 532-570 series
Organic compounds
C536S004100, C536S005000
Reexamination Certificate
active
07144994
ABSTRACT:
A new isoform of manganese superoxide dismutase (MnSOD) and polynucleotides encoding it have been identified. This isoform, MnSOD E3(−), is a splice variant lacking exon 3 of the full length MnSOD. The polypeptide can be expressed using appropriate host cells. Modulation of either the expression of the polynucleotides of the activity of the polypeptide is also described. Furthermore, diagnostic and therapeutic methods have been developed as a consequence of the isolation of the polynucleotides and polypeptides.
REFERENCES:
patent: 5240847 (1993-08-01), Heckl et al.
Verma et al., Gene therapy—promises, problems and prospects Nature 389, pp. 239-242, Sep. 18, 1997.
Ausubel, et al., “Introduction to Expression by Fusion Protein Vectors,” in Curr. Prot. Mol. Biol., (Wiley), 1990, 2:16.4.1-16.5.6.
Li, et al., “Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase,” Nature Genet. (1995) 11:376-381.
Pitkanen, et al., “Mitochondrial complex I deficiency leads to increased production of superoxide radicals and induction of superoxide dismutase,” J. Clin. Invest. (1996) 98:345-351.
Robinson, “The role of superoxide dismutase in health and disease,” J. Inher. Metab. Dis. (1998) 21:598-603.
Anziano Paul
Campell Bruce R.
Hill Myron G.
O'Connor P.C. Cozen
LandOfFree
Manganese superoxide dismutase exon 3-deleted isoforms and... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Manganese superoxide dismutase exon 3-deleted isoforms and..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Manganese superoxide dismutase exon 3-deleted isoforms and... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3660429