Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Reexamination Certificate
2007-06-05
2007-06-05
Campell, Bruce R. (Department: 1648)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
C530S389100
Reexamination Certificate
active
11098072
ABSTRACT:
A new isoform of manganese superoxide dismutase (MnSOD) and polynucleotides encoding it have been identified. This isoform, MnSOD E3(−), is a splice variant lacking exon 3 of the full length MnSOD. The polypeptide can be expressed using appropriate host cells. Modulation of either the expression of the polynucleotides of the activity of the polypeptide is also described. Furthermore, diagnostic and therapeutic methods have been developed as a consequence of the isolation of the polynucleotides and polypeptides.
REFERENCES:
Ausubel, et al., “Introduction to Expression by Fusion Protein Vectors,” in Curr. Prot. Mol. Biol., (Wiley), 1990, 2:16.4.1-16.5.6.
Li, et al., “Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase,” Nature Genet. (1995) 11:376-381.
Pitkanen, et al., “Mitochondrial complex I deficiency leads to increased production of superoxide radicals and induction of superoxide dismutase,” J. Clin. Invest. (1998) 98:345-351.
Robinson, “The role of superoxide dismutase in health and disease,” J. Inher. Metab. Dis. (1998) 21:598-603.
Campell Bruce R.
Cozen O'Connor P.C.
Hill Myron G.
Trujillo Doreen Yatko
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