Mandelic acid derivatives and their use as thrombin inhibitors

Details Mandelic acid derivatives and their use as thrombin inhibitors Mandelic acid derivatives and their use as thrombin inhibitors

2006-10-31

2006-10-31

Saeed, Kamal A. (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C514S210170, C548S952000, C548S953000

Reexamination Certificate

active

07129233

ABSTRACT:
There is provided a compound of formula Iwherein Ra, R1, R2, Y and R3have meanings given in the description and pharmaceutically-acceptable derivatives (including prodrugs) thereof, which compounds and derivatives are useful as, or are useful as prodrugs of, competitive inhibitors of trypsin-like proteases, such as thrombin, and thus, in particular, in the treatment of conditions where inhibition of thrombin is required (e.g. thrombosis) or as anticoagulants.

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U.S. Appl. No. 10/487,805.

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