Mandelic acid derivatives and their use as thrombin inhibitors

Details Mandelic acid derivatives and their use as thrombin inhibitors Mandelic acid derivatives and their use as thrombin inhibitors

2006-06-06

2006-06-06

Saeed, Kamal A. (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C514S210170, C548S952000, C548S953000

Reexamination Certificate

active

07056907

ABSTRACT:
There is provided a compound of formula (1) and pharmaceutically-acceptable derivatives (including prodrugs) thereof. Which compound and derivatives are useful as, or are as useful as prodrugs of, competitive inhibitors of trypsin-like proteases, such as thrombin, and thus in particular, in the treatment of conditions where inhibition of thrombin is required (e.g. thrombosis) or as anticoagulants.

REFERENCES:
patent: 6051568 (2000-04-01), Gustafsson et al.
patent: 6599894 (2003-07-01), Inghardt et al.
patent: 2004/0019033 (2004-01-01), Inghardt et al.
patent: WO-97/02284 (1997-01-01), None
patent: WO-00/42059 (2000-07-01), None
patent: WO-02/14270 (2002-02-01), None
U.S. Appl. No. 10/432,411.

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