Mandelic acid derivatives

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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C514S238500, C514S275000, C514S315000, C514S349000, C514S351000, C514S352000, C514S364000, C514S394000, C514S415000, C514S428000, C514S460000, C514S471000, C514S619000, C544S105000, C544S168000, C544S332000, C546S242000, C546S297000, C546S300000, C546S311000, C548S131000, C548S309700, C548S494000, C548S567000, C549S419000, C549S496000, C564S163000

Reexamination Certificate

active

07129238

ABSTRACT:
The invention is concerned with novel mandelic acid derivatives of formula (I)wherein R1to R10, X and Y are as defined in the description and in the claims, as well as pharmaceutically acceptable salts thereof.These compounds inhibit the formation of coagulation factors Xa, IXa and thrombin induced by factor VIIa and tissue factor.

REFERENCES:
patent: 5292769 (1994-03-01), Mohrs et al.
patent: 6060491 (2000-05-01), Pruitt et al.
patent: 7001887 (2006-02-01), Shiraishi et al.
patent: WO 00 35858 (1999-12-01), None
patent: WO 2004/048335 (2004-06-01), None
Shiraishi et al, STN International, HCAPLUS Database, Columbus, OH, Accession No. 2002:615652, Reg. No. 446846-14-6 and 446846-17-9 (2006).
Dixon, M. “The Determination of Enzyme Inhibitor Constants” Biochem J. vol. 55 (1953) pp. 170-171.
Su, et al., Science Direct-Biorganic & Medicinal Chemistry Letters, pp. 2279-2282 (2001).

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