Chemistry: molecular biology and microbiology – Vector – per se
Patent
1996-10-07
1998-06-30
Ketter, James
Chemistry: molecular biology and microbiology
Vector, per se
536 241, C07H 2104, C12N 1570
Patent
active
057732906
ABSTRACT:
An isolated DNA fragment comprising a mammary gland-specific promoter is disclosed. Preferably, this promoter promotes gene expression throughout the estrous cycle in a constant manner. In one embodiment, the promoter comprises nucleotides 1154 through 2967 of SEQ ID NO:1 or 1102 through 2910 of SEQ ID NO:2.
REFERENCES:
Bundgaard, J. et al. 1994, Biochemical and Biophysical Research Communications vol. 202 No. 3 pp. 1468-1475.
J. Drouin, et al., "Glucocorticoid receptor binding to a specific DNA sequence is required for horomone-dependent repression of pro-opiomelanocortin gene transcription," Molec. Cell. Biol. 9(12):5305-5314, 1989.
E. Garay-Rojas, et al., "An apparent autocrine mechanism amplifies the dexamethasone- and retinoic acid-induced expression of mouse lipocalin-encoding gene 24p3," Gene 170:173-180, 1996.
S. Hraba-Renevey, et al., "SV40-induced expression of mouse gene 24p3 involves a post-transcriptional mechanism," Oncogene 4:601-608, 1989.
S. Li and J. Rosen, "Glucocorticoid regulation of rat whey acidic protein gene expression involves hormone-induced alterations of chromatin structure in the distal promoter region," Molec. Endocrin. 8(10): 1328-1335, 1994.
A. Ray and K. Prefontaine, "Physical association and functional antagonism between the p65 subunit of transcription factor nf-.kappa.b and the glucocorticoid receptor," Proc. Natl. Acad. Sci. USA 91:752-756, 1994.
D. Sakai, et al., "Hormone-mediated repression: a negative glucocorticoid response element from the bovine prolactin gene," Genes & Dev. 2:1144-1154, 1988.
B. Stein and M. Yang, "Repression of the interleukin-6 promoter by estrogen receptor is mediated by NF-.kappa.B and C/EBP.beta.," Molec. Cell. Biol. 15(9):4971-4979, 1995.
S. Stoesz and M. Gould, "Overexpression of neu-related lipocalin (NRL) in neu-initiated but not ras or chemically initiated rat mammary carcinomas," Oncogene 11:2233-2241, 1995.
M. Truss, et al., "Interplay of steroid hormone receptors and transcription factors on the mouse mammary tumor virus promoter," J. Steroid Biochem. Molec. Biol. 43(5):365-378, 1992.
D. White, et al., "Structure and chromosomal localization of the human gene for a brain form of prostaglandin D.sub.2 synthase," J. Biol. Chem. 267(32):23202-23208, 1992.
Chen Kai-Shun
Gould Michael N.
Ketter James
Wisconsin Alumni Research Foundation
Yurel Irem
LandOfFree
Mammary gland-specific promoters does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Mammary gland-specific promoters, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Mammary gland-specific promoters will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1858070