Mammalian tub gene

Details Mammalian tub gene Mammalian tub gene

1996-04-12

1997-07-08

Fleisher, Mindy

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

4353201, 435348, 435419, 435357, 435358, 435364, 435365, 435369, 536 235, 536 243, 536 2431, C12N 510, C12N 1511, C12N 1512, C12N 1563

Patent

active

056460406

ABSTRACT:
The present invention relates to the identification of novel nucleic acid molecules and proteins encoded by such nucleic acid molecules or degenerate variants thereof, that participate in the control of mammalian body weight. The nucleic acid molecules of the present invention represent the genes corresponding to the mammalian tub gene, a gene that is involved in the regulation of body weight.

REFERENCES:
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Noben-Trauth et al., Nature 380:534-538 (1996).
Freidman, J.M. et al., 1991, "Molecular Mapping of Obesity Genes", Mamm. Genome 1:130-144.
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Friedman, J.M. and Leibel, R.L., 1992, "Tackling a Weighty Problem", Cell 69:217-220.
Coleman, D.L. and Eicher, E.M., 1990, "Fat (fat) and Tubby (tub): Two Autosomal Recessive Mutations Causing Obesity Syndromes in the Mouse", J. Hered. 81:424-427.
Jones, J.M. et al., 1992, "Localization of Insulin-2 (Ins-2) and the Obesity Mutant Tubby (tub) to Distinct Regions of Mouse Chromosone 7", Genomics 14:197-199.
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Warden, C.H. et al., 1995, "Identification of Four Chromosomal Loci Determining Obesity in a Multifactorial Mouse Model", J. Clin. Invest. 95:1545-1552.
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Heckenlively, J.R. et al., 1995, "Mouse Model for Usher Syndrome: Linkage Mapping Suggests Homology to Usher Type I Reported at Human Chromosome 11p15", Proc. Natl. Acad. Sci. USA 92:11100-11104.
Chung, W.K. et al., 1996, "Molecular Mapping of the Tubby (tub) Mutation on Mouse Chromosome 7", Genomics 32:210-217.
Genbank Accession No. X69827 NCBI Entrez Record.
Vambutas, V. and Wolgemuth, D.J., 1994, "Identification and Characterization of the Developmentally Regulated Pattern of Expression in the Testis of a Mouse Gene Exhibiting Similarity to the Family of Phosphodiesterases", Biochim. Biophys. Acta 1217:203-206.
Genbank Accession No. Z48334 NCBI Entrez Record.
Wilson, R. et al., 1994, "2.2 Mb of Contiguous Nucleotide Sequence from Chromosome III of C. elegans", Nature 368:32-38.
Genbank Accession No. Z50688 NCBI Entrez Record.
Genbank Accession No. H92408 NCBI Entrez Record.

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