Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Hormones – e.g. – prolactin – thymosin – growth factors – etc.
Patent
1998-02-10
1999-11-09
Kemmerer, Elizabeth
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Hormones, e.g., prolactin, thymosin, growth factors, etc.
530350, C07K 14435, C07K 14475
Patent
active
059817178
ABSTRACT:
A mammalian gene encoding a tolloid-like protein distinct from human or murine BMP-1/mTld is presented. The gene is similar in structure to members of the BMP-1 family of genes, but maps to a distinct location and encodes a distinct protein. The protein encoded by the gene can be used to screen putative therapeutic agents in an ongoing effort to inhibit activity of the BMP-1 family of genes to prevent scarring, fibrosis, and the like.
REFERENCES:
Bond, Judith S. et al., "The Astacin Family of Metalloendopeptidases," Protein Science, 4:1247-1261 (1995).
Crystal, Ronald, Science, 270: 404-409 (1995).
Greenspan, D.S., "Mus Musculus Mammalian Tolloid-like Protein mRNA", Genbank Accession Number U34042 (1996).
Johnson, George, "The Chicken with the Duck's Feet: It's All in the Biochemical Signal," The New York Times Science May 21, 1996.
Kessler, Efrat, et al., "Bone Morphogenetic Protein-1: Type 1 Procollagen C-Proteinase", Science, 271: 360-362 (1996).
Mastrangelo et al., Seminars in Oncology, 23(1): 4-21 (1996).
Takahara, Kazuhiko, et al., Bone Morphgenetic Protein-1 and a Mammalian Tolloid Homologue (mTld) are Encoded by Alternatively Spliced Transripts Which Are Differentially Expressed in Some Tissues, The Journal of Biological Chemistry, 269(51): 32572-32578 (1994).
Takahara, Kazuhiko et al., "Structural Organization and Genetic Localization of the Human Bone Morphogenetic Protein 1/Mammaliain Tolloid Gene", Genomics, 29(1): 9-15 (1995).
Takahara, Kazuhiko et al., "Characterization of a Novel Gene Product (Mammalian Tolloid-Like) with High Sequence Similarity to the Mammilian Tolloid/Bone Morphogenetic Protein-1", Genomics, 34(2): 157-165 (1996).
Greenspan Daniel S.
Hoffman Guy G.
Takahara Kazuhiko
Kemmerer Elizabeth
Wisconsin Alumni Research Foundation
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