Mammalian tolloid-like gene and protein

Details Mammalian tolloid-like gene and protein Mammalian tolloid-like gene and protein

1997-05-30

1999-08-17

Campell, Bruce R.

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

435 691, 4353201, 435455, 514 44, 424 9321, 536 231, C12N 1500

Patent

active

059393211

ABSTRACT:
A mammalian gene encoding a tolloid-like protein distinct from human or murine BMP-1/mTld is presented. The gene is similar in structure to members of the BMP-1 family of genes, but maps to a distinct location and encodes a distinct protein. The protein encoded by the gene can be used to screen putative therapeutic agents in an ongoing effort to inhibit activity of the BMP-1 family of genes to prevent scarring, fibrosis, and the like.

REFERENCES:
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Ngo et al., in: The Protein Folding Problem and Tertiary Structure Prediction, 1994, Merz et al., (ed.), Birkhauser, Boston, MA, pp. 433 and 492-495.
Bond, Judith S., et al., "The astacin family of metalloendopeptidases," Protein Science, 4:1247-1261 (1995).
Johnson, George, "The Chicken With a Duck's Feet: It's All in the Biochemical Signal," The New York Times Science (May 21, 1996).
Kessler, Efrat, et al., "Bone Morphogenetic Protein-1: The Type I Procollagen C-Proteinase," Science, 271:360-362 (Jan. 19, 1996).
Takahara, Kazuhiko, et al., "Bone Morphogenetic Protein-1 and a Mammalian Tolloid Homologue (mTld) Are Encoded by Alternatively Spliced Transcripts Which Are Differentially Expressed in Some Tissues," The Journal of Biological Chemistry, 269(51):32572-32578 (1994).

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