Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Reexamination Certificate
2006-11-14
2006-11-14
Helms, Larry R. (Department: 1643)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
C530S388260, C530S388100, C530S391100, C530S391700, C424S139100, C424S141100, C424S146100, C424S178100, C435S070210
Reexamination Certificate
active
07135555
ABSTRACT:
The present invention provides isolated human and bovine TNF-α convertases, nucleic acids and recombinant vectors encoding the same, host cells comprising the nucleic acids and vectors, and methods for making the convertases using the host cells. This invention further provides antibodies and antigen binding fragments thereof which specifically bind to the convertases and are useful for treating medical conditions caused or mediated by TNF-α. Also provided are screening methods for identifying specific inhibitors of mammalian TNF-α convertases, and for identifying nucleic acids encoding such convertases.
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Dalie Barbara
Fan Xuedong
Lundell Daniel
Lunn Charles A.
Tan Jimmy C.
Biro Michael G.
Blanchard David J.
Helms Larry R.
Henderson Melodie W.
Reed Grant E.
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