Mammalian telomerase

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing compound containing saccharide radical

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

435194, 4352401, 43525411, 4352523, 4353201, 435 911, 4351723, 435 9131, 536 231, 536 232, 536 2431, 536 2433, 935 8, 935 9, 935 14, 935 10, 935 66, C12P 1934, C12N 121, C12N 510, C12N 1554

Patent

active

055830161

ABSTRACT:
Nucleic acids comprising the RNA component of a mammalian telomerase are useful as pharmaceutical, therapeutic, and diagnostic reagents.

REFERENCES:
patent: 4737454 (1988-04-01), Dattagupta et al.
patent: 5270201 (1993-12-01), Richards et al.
N. Kim et al. (1994) Science 266:2011-2014. Specific Association of Human Telomerase Activity with Immortal Cells and Cancer.
J. Feng et al. (1995) Science 269:1236-1241. The RNA Component of Human Telomerase.
Prowse et al. (1993) Proc. Nat. Acad. Sci., USA, 90: 1493-.
Yan et al. (1992) J. Biological Chemistry 267: 23226-23231.
J. Rennie (1994) Scientific American, Jul. pp. 14-16. Immortal's Enzyme.
B. Rensberger Washington Post, Apr. 12, 1994, pp. A1, A12. Cancer's Immortality May Depend on Enzyme.
Counter et al. (1994) PNAS 91:2900-2904. Telomerase activity in human ovarian carcinoma.
P. Nilsson et al. (1994) Oncogene 9:3043-3048. Telomerase activity in vivo in human malignant hematopoietic cells.
C. W. Greider (1993) Cold Spring Harbor Symposia on Quantitative Biology, vol. LVIII, Cold Spring Harbor Laboratory, NY. Telomerase and Telomere-length Regulation: Lessons from Small Eukaryotes to Mammals.
E. H. Blackburn (1991) TIBS 16:378-381. Telomeres.
Grant Abstracts: (no publication year) Elizabeth Blackburn--5R01 GM 32565-11; 5P30 ES01896-15UB: 9024; 5R37 GM26259-16. Carol Greider--5R01 RG09383-03; 5R01GM43080-04.
Blackburn (1991), Structure and function of telomeres, Nature 350:569-573.
Blackburn (1992), Telomerases, Ann. Rev. Biochem. 61:113-129.
Blackburn et al. (1989), Recognition and elongation of telomeres by telomerase, Genome 31:553-560.
Counter et al. (1992), Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity, EMBO J. 11(5):1921-1929.
Czech (25 Nov. 1988), Ribozymes and their medical implications, JAMA 260(20):3030-3034.
Eck and Nabel (1991), Antisense oligonucleotides for therapeutic intervention, Current Opinions Biotechnology 2:897-904.
Greider (Sep. 1991), Telomerase is processive, Mol. Cell. Bio. 11:4572-4580.
Greider and Blackburn (24 Dec. 1987), The telomere terminal transferase of Tetrahymena is a ribonucleoprotein enzyme with two kinds of primer specificity, Cell 51:887-898.
Greider and Blackburn (26 Jan. 1989), A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis, Nature 337(6205):331-337.
Harley et al. (31 May 1990), Telomeres shorten during ageing of human fibroblasts, Nature 345:458-460.
Harley et al. (1991), Telomere loss: Mitotic clock or genetic time bomb? Mut. Res. 256:271-282.
Morin (3 Nov. 1989), The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG Repeats, Cell, 59:521-529.
Morin (8 Oct. 1991), Recognition of a chromosome truncation site associated with alpha-thalassaemia by human telomerase, Nature 353:454-456.
Romero and Blackburn (18 Oct. 1991), A conserved secondary structure for telomerase RNA, Cell 67:343-353.
Shippen-Lentz and Blackburn (2 Feb. 1990), Functional evidence for an RNA template in telomerase, Science 247:546-552.
Yu et al. (8 Mar. 1990), In vitro alteration of telomere sequences and senescence caused by mutated Tetrahymena telomerase RNAs, Nature 344:126-132.
Yu and Blackburn (15 Nov. 1991), Developmentally programmed healing of chromosomes by telomerase in Tetrahymena, Cell 67: 823-832.
Zahler et al. (25 Apr. 1991), Inhibition of telomerase by G-quartet DNA structures, Nature 350:718-720.
Lingner et al. (1984), Telomerase RNAs of different ciliates have a common secondary structure and a permuted template, Genes and Development 8:1989-1998.
Singer and Gottschling (1994), TLC1: Template RNA Component of Saccharomyces cerevisiae Telomerase, Science 266:404-409.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Mammalian telomerase does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Mammalian telomerase, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Mammalian telomerase will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-423482

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.