Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Reexamination Certificate
2006-01-17
2006-01-17
Shukla, Ram R. (Department: 1632)
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
C536S023100, C435S320100, C435S325000
Reexamination Certificate
active
06987003
ABSTRACT:
The present invention relates to mammalian staufen, a double-stranded RNA-binding protein involved in mRNA transport and localization. The invention further relates to the demonstration of the association of a RNA-binding protein with the rough endoplasmic reticulum (RER), implicating staufen and related proteins in the transport of RNA to its site of translation. Broadly, the invention therefore relates to transport and translation of RNA. More specifically, the present invention relates to human and mouse staufen proteins and to the modulation of transport of RNA to the RER by these proteins. The present invention also relates to isolated nucleic acid molecules encoding mammalian staufen, as well as vectors and host cells harboring same. In addition, the present invention relates to screening assays for identifying modulators of staufen activity and to the identification of mutants thereof which abrogate their interaction with RER. Furthermore, the present invention relates to the use of the double-stranded RNA binding activity of staufen as a means to target proteins into virions. The invention in addition relates to the incorporation of staufen into RNA viruses and the use of overexpression of staufen to significantly decrease the infectivity thereof. More particularly, the present invention relates to a novel and broad class of molecules which can be used as carriers to target molecules into virions of RNA viruses and to decrease infectivity of a wide variety of RNA viruses including retroviruses.
REFERENCES:
Rudinger; Characteristics of the amino as components of a peptide hormone sequence, 1976, Peptide Hormones; 1-7.
Johnston et al.; Accession No. M69111.1, 1993.
Marra et al.; Accession No. AA122533, 1997.
Banfi et al.; Accession No. G30939, 1998.
Ainger et al. 1993, J. Cell. Biol. 123:431-441.
Aloyz et al. 1995, Peptides 16:331-338.
Arya et al. 1985, Science 229:69-73.
Bassell et al. 1997, Curr. Opin. Cell Biol. 9:109-115.
Benkirane et al. 1997, EBMO J. 16:611-624.
Bergeron et al. 1991, J. Virol. 65:7-15.
Berkowitz et al. 1995, Virology 212:718-723.
Berlioz et al. 1995, J. Virol. 69:2214-2222.
Bertrand et al. 1998, Mol. Cell 2:437-445.
Breitwieser et al. 1996, Genes & Dev. 10:2179-2188.
Broadus et al. 1998, Nature 391:792-795.
Circle et al. 1997, RNA 3:438-448.
Cogniaux et al. 1990, J. Immunol. Meth. 128:165-175.
Cosentino et al. 1995, Proc. Natl. Acad. Sci USA 92:9445-9449.
Crino et al. 1996, Neuron 17:1173-1187.
Dannull et al. 1994, EMBO J. 13:1525-1533.
Davis et al. 1987, Nature 330:447-479.
Dayton et al. 1986, Cell 44:941-947.
De Guzman et al. 1998, Science 279:384-388.
DesGroseillers et al. 1996, Genomics 36:527-529.
Deshler et al. 1997, Science 276:1128-1131.
Deshler et al. 1998, Curr. Biol. 8:489-496.
Donzeau et al. 1997, J. Virol. 71:2628-2635.
Dorfman et al. 1993, J. Virol. 67:6159-6169.
Eckmann et al. 1997, J. Cell Biol. 138:239-253.
Elisha et al. 1995, EMBO J. 14:5109-5114.
Ephrussi et al. 1991, Cell 66:37-50.
Erdélyl et al. 1995, Nature 377:524-527.
Falcón et al. 1999, Nucleic Acids Research 27:2241-2247.
Ferrandon et al. 1994, Cell 79:1221-1232.
Ferrandon et al. 1997, EMBO J. 16:1751-1758.
Forristall et al. 1995, Development 121:201-208.
Fortin et al. 1998, J. Virol. 72:2105-2112.
Fortin et al. 1997, J. Virol. 71:3588-3596.
Gatignol et al. 1993, Mol. Cell. Biol. 13:2193-2202.
Gatignol et al. 1991, Science 251:1597-1600.
Gazzaley et al. 1997, J. Neurosci. 17:2006-2017.
Gorelick et al. 1993, J. Virol. 67:4027-4036.
Gorelick et al. 1990, J. Virol. 64:3207-3211.
Harrison et al. 1995, J. Virol. 69:2175-2186.
Havin et al. 1998, Genes & Development 12:1593-1598.
Hochstenbach et al. 1992, Proc. Natl. Acad. Sci. 89:4734-4738.
Huang et al. 1997, J. Virol. 71:4378-4384.
Jockers et al. 1996, J. Biol. Chem. 271:9355-9362.
Kang et al. 1996, Science 273:1402-1406.
Kiebler et al. 1999, J. Neuroscience 19:1-10.
Kim-Ha et al. 1991, Cell 66:23-35.
Kim-Ha et al. 1995, Cell 81:403-412.
Kimpton et al. 1992, J. Virol. 66:2232-2239.
Kislauskis et al. 1997, J. Cell Biol. 136:1263-1270.
Kloc et al. 1994, Science 265:1101-1103.
Knowles et al. 1996, J. Neuroscience 16:7812-7820.
Kraut et al. 1996, Dev. Biol. 174:65-81.
Krovat et al. 1996, J. Biol. Chem. 271:28112-28119.
Laughrea et al. 1997, J. Virol. 71:3397-3406.
Lever et al. 1989, J. Virol. 63:4085-4087.
Li et al. 1997, Cell 90:437-447.
Long et al. 1997, Science 277:383-387.
Marión et al. 1999, Mol. Cell. Biol. 19:2212-2219.
Martin et al. 1997, Cell 91:927-938.
McBride et al. 1997, J. Virol. 71:4544-4554.
McCormack et al. 1994, Virology 198:92-99.
Miele et al. 1996, J. Virol. 70:944-951.
Mizuno et al. 1996, AIDS Res. Hum. Retrov. 12:793-800.
Mouland et al. 1992, Mol. Endocrinol. 6:1781-1788.
Nakielny et al. 1997, Annu. Rev. Neurosci. 20:269-301.
Okita et al. 1994, Trends Cell Biol. 4:91-96.
Ott et al. 1995, AIDS Res. Hum. Retrov. 11:1003-1006.
Ott et al. 1996, J. Virol. 70:7734-7743.
Pachter, J.S. 1992, Crit. Rev. Euk. Gene Exp. 2:1-18.
Palker et al. 1989, J. Immunol. 142:3612-3619.
Park et al. 1994, Proc. Natl. Acad. Sci USA 91:4713-4717.
Pokrywka et al. 1995, Dev. Biol. 167:363-370.
Poon et al. 1998, J. Virol. 72:1983-1993.
Rings et al. 1994, Eur. J. Cell. Biol. 63:161-171.
Ross et al. 1997, Mol. Cell. Biol. 17:2158-2165.
Schmedt et al. 1995, J. Mol. Biol. 249:29-44.
Schumacher et al. 1995, J. Cell Biol. 129:1023-1032.
Schwartz et al. 1992, Proc. Natl. Acad. Sci. USA 89:11895-11899.
St Johnston et al. 1992, Proc. Natl. Acad. Sci. USA 89:10979-10983.
St Johnston et al. 1991, Cell 66:51-63.
St Johnston et al. 1995, Cell 81:161-170.
St Johnston et al. 1989, Dev. (Suppl.) 107:13-19.
Steimer et al. 1986, Virology 150:283-290.
Steward, O. 1997, Neuron 18:9-12.
Takizawa et al. 1997, Nature 389:90-93.
Terasaki et al. 1986, J. Cell. Biol. 103:1557-1568.
Tetzlaff et al. 1996, The EMBO Journal 15:1247-1254.
Tiedge et al. 1993, J. Neurosci. 13:4214-4219.
Tiedge et al. 1991, Proc. Natl. Sci. USA 88:2093-2097.
Tongiorgi et al. 1997, J. Neurosci. 17:9492-9505.
Wickham et al. 1999, Mol. Cell. Biol. 19:2220-2230.
Wickham et al. 1991, DNA and Cell Biol. 10:249-258.
Wilheim et al. 1993, J. Cell Biol. 123:269-274.
Wilsch-Bräuninger et al. 1997, J. Cell Biol. 139:817-829.
Zauner et al. 1992, Eur. J. Cell Biol. 57:66-74.
Zhu et al. 1997, J. Biol. Chem. 272:14434-14441.
Cohen Eric A.
Desgroseillers Luc
Duchaîne Thomas
Luo Ming
Mouland Andrew J.
Goudreau Gage Dubuc
Hama Joanne
Shukla Ram R.
Universite de Montreal
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