Multicellular living organisms and unmodified parts thereof and – Method of using a transgenic nonhuman animal in an in vivo...
Reexamination Certificate
2006-07-06
2009-10-13
Paras, Jr., Peter (Department: 1632)
Multicellular living organisms and unmodified parts thereof and
Method of using a transgenic nonhuman animal in an in vivo...
C800S008000, C800S018000
Reexamination Certificate
active
07601883
ABSTRACT:
Acid/sour taste receptors are provided. CSF pH sensing receptors are provided. Methods and systems for screening for tastants and receptor modulators are provided. Knock out and transgenic animals, antibodies to the receptors, methods of detecting polymorphisms, and methods of correcting taste defects are also provided.
REFERENCES:
patent: 2002/0037515 (2002-03-01), Margolskee et al.
patent: 2002/0127623 (2002-09-01), Minshull et al.
patent: WO 00/44929 (2000-08-01), None
patent: WO 00/45179 (2000-08-01), None
patent: WO 03/025137 (2003-03-01), None
patent: WO 2004/034025 (2004-04-01), None
patent: WO 2005/061548 (2005-07-01), None
Ristevski et al., Molecular Biotechnology, vol. 29, 2005, pp. 153-163.
Montoliu et al., 2002, Cloning and Stem Cells, vol. 4, pp. 39-46.
Houdebine et al., 2002, J. of Biotechnology, vol. 98, pp. 145-160.
Zhao et al., 2003, Cell, vol. 115, pp. 255-266.
Baker et al., 2000, Int. J. Human-Computer Studies, vol. 52 pp. 1-16.
Rossant et al., 1998, TIG, vol. 14(9) pp. 358-363.
Huang et al., 2006, Nature, vol. 442(7105), pp. 934-938.
Alexander et al. (1992) “Altering the antigenicity of proteins”Proc. Natl. Acad. Sci. USA89: 3352-3356.
Avenet & Lindemann (1989) “Perspectives in taste reception”J Membr Biol.112, 1-8.
Basora et al. (2002) “Tissue and Cellular Localization of a Novel Polycystic Kidney Disease-Like Gene Product, Polycystin-L”J. Am. Soc. Nephrol13:293-301.
Bernhardt et al. (1996) “Changes in IP3and cytosolica CA2+in response to sugards and non-sugar sweeteners in transduction of sweet tast in the rat”J. Physiol490:325-336.
Bowie et al. (1990) “Deciphering the Message in Protein Sequences: Tolerance to Amino Acid Substitutions”Science247:1306-1310.
Doolin et al. (1996) “Distribution and Characterization of Functional Amiloride-sensitive Sodium Channels in Rat Tongue”J. Gen. Physiol. 107: 545-554.
Gilbertson et al., “The molecular physiology of taste transduction”Curr. Opin. Neurobiol. 10: 519-527, 2000.
Hoon et al. (1999) “Putative mammalian taste receptors: a class of taste-specific GPCRs with distinct topographic selectivity”Cell96:541-51.
Kinnamon et al., (1992) “Chemosensory transduction mechanisms in taste”Annu. Rev. Physiol. 54:715-731.
Lin and Corey (2005) “TRP channels in mechanosensation”Curr Opin Neurobiol. 15(3):350-7.
Lindemann (1996) “Taste reception”Physiol. Rev. 76:718-766.
Liu et al. (2003) “Intracellular Ca2+and the phospholipids PIP2regulate the taster transduction ion channel TRPM5”Proc. Natl. Acad. Sci. USA100(25): 15160-15165.
Madden et al. (1997) “Taste Perception in Cirrhosis: Its Relationship to Circulating Micronutrients and Food Preferences”Hepatology26(1): 40-48.
Margolskee (1993) “The molecular biology of taste transduction”R. Bioessays15, 645-650.
Mueller et al. (2005) “The receptors and coding logic for bitter taste”Nature434 (7030): 225-9.
Nauli and Zhou 2004 “Polycystins and Mechanosensation in renal and nodal cilia”Bioessays26.8 844-856.
Nelson et al. (2001) “Mammalian sweet taste receptors”Cell106(3): 381-90.
Nelson et al. (2002) “An amino-acid taste receptor”Nature416(6877): 199-202.
Nomura, et al. (1998) “Identification of PKDL, a novel polycystic kidney disease 2-like gene whose murine homologue is deleted in mice with kidney and retinal defects”J. Biol.Chem. 273:25967-25973.
Ogura et al. (1997) “Bitter Taste Transduction of Denatonium in the MudpuppyNecturus Maculosus,” J. of Neuroscience, 17(10): 3580-3587.
Roper et al. (1989) “Distribution of Ion Channels on Taste Cells and its Relations to Chemosensory Transduction,”J. Membrane Biology109(1): 29-39.
Roper (1989) “The cell biology of vertebrate taste receptors”Ann. Rev. Neurosci. 12:329-353.
Wu et al. (1998) “Identification of PKD2L, a Human PKD2-Related Gene: Tissue-specific Expression and Mapping to Chromosome 10q25”Genomics54(3) 564-568.
Zhang et al. (2003) “Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways”Cell112(3):293-301.
Zhao et al. (2003) “The receptors for mammalian sweet and umami taste”Cell115(3):255-66.
Chen et al. (1999) “Polycystin-L is a calcium-regulated cation channel permeable to calcium ions.”Nature, 401: 383-385.
Inoue et al. (2003) “Transient Receptor Potential Protein as a Novel Non-Voltage-Gated Ca+2Entry Channel Involved in Diverse Pathophysiological Functions.”Journal of Pharmacological Sciences, 91: 271-276.
Vigh et al. (2004) “The system of cerebrospinal fluid-contacting neurons. Its supposed role in the nonsynaptic signal transmission of the brain.”Histol Histopathol, 19(2): 607-628.
Huang Angela L.
Zuker Charles
Littlepage Paul
Montanari David
Paras, Jr. Peter
Quine Jonathan Alan
Quine Intellectual Property Law Group P.C.
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