Mammalian receptors for interleukin-10 (IL-10)

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...

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4352523, 4353201, 536 235, 536 243, C12N 1512

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active

057891923

ABSTRACT:
Receptor components for IL-10 are isolated and characterized. The amino acid sequence and nucleic acid encoding various species variants of the receptors are disclosed. Uses of the purified receptor gene and polypeptide are disclosed, including means for screening for agonists and antagonists of the receptor ligands, for producing diagnostic or therapeutic reagents, and for producing antibodies. Therapeutic or diagnostic reagents and kits are also provided.

REFERENCES:
Tan et al, JBC 268(28) 1993, pp. 21053-21059.
Chow et ak, The FASEB Journal 7(7) 1993, #350, p. A1112.
Kuczmarski et al, Blood Review, 5(3) 1991, pp. 193-203.
Cusman, Cytokine 5(2) 1993, pp. 95-106.
J. Fernando Bazan, "Structural design and molecular evolution of a cytokine receptor superfamily," PNAS, vol. 87, pp. 6934-6938, Sep. 1990.
Renede Waal Malefyt, et al., "Interleukin 10 (IL-10) Inhibits Cytokine Synthesis by Human Monocytes: An Autoregulatory Role of IL-10 Produced by Monocytes," J. Exp. Med., vol. 174, pp. 1209-1220, Nov. 1991.
David F. Fiorention, et al., "IL-10 Inhibits Cytokine Production By Activated Macrophages," J. Immunol., vol. 147, pp. 3815-3822, 1991.
David F. Fiorentino, et al., "Two Types Of Mouse T Helper Cell IV. Th2 Clones Secrete a Factor that Inhibits Cytokine Production by Th1 Clones," J. Exp. Med., vol. 170, pp. 2081-2095, Dec. 1989.
David P. Gearing, et al., "Expression cloning of a receptor for human granulocyte-macrophage colony-stimulating factor," The EMBO Journal, vol. 8, No. 12, pp. 3667-3676, 1989.
Kazuhiro Hayashida, et al., "Molecular cloning of a second subunit of the receptor for human granulocyte-macrophage colony-stimulating factor (GM-CSF) : Reconstitution of a high-affinity GM-CSF receptor," PNAS, vol. 87, pp. 9655-9659, Dec. 1990.
Di-Hwei Hsu, et al., "Differential effects of IL-4 and IL-10 on IL-2-induced IFN-.gamma.synthesis and lymphokine-activated killer activity," International Immunology, vol. 4, No. 5, pp. 563-569, 1992.
Di-Hwei Hsu, et al., "Expression of Interleukin-10 Activity by Epstein-Barr Virus Protein BCRF1," Science, vol. 250, pp. 830-832, Nov. 1990.
Hiroshi Ishida, et al., "Continuous Anti-Interleukin 10 Antibody Administration Depletes Mice of Ly-1 B Cells but Not Conventional B Cells," J. Exp. Med., vol. 175, pp. 1213-1220, May 1992.
Naoto Itoh, et al., "Cloning of an Interleukin-3 Receptor Gene: A Member of a Distinct Receptor Gene Family," Science, vol. 247, pp. 324-327, Jan. 1990.
Kevin W. Moore et al., "Homology of Cytokine Synthesis Inhibitory Factor (IL-10) to the Epstein-Barr Virus Gene BCRFI," Science, vol. 248, pp. 1230-1234, Jun. 1990.
Tim R. Mosmann, et al., "The role of IL-10 in crossregulation of T.sub.h 1 and T.sub.h 2 responses," Immunology Today, vol. 12, pp. A49-A53, 1991.
Stephen P. Squinto, et al., "Identification of Functional Receptors for Ciliary Neurotrophic Factor on Neuronal Cell Lines and Primary Neurons," Neuron, vol. 5, pp. 757-766, Dec. 1990.
Jan Tavernier, et al., "A Human High Affinity Interleukin-5 Receptor (IL5R) Is Composed of an IL5-Specific .alpha. Chain and a .beta. Chain Shared with the Receptor for GM-CSF," Cell, vol.66, pp. 1175-1184, Sep. 20, 1991.
P. Vieira, et al., "Isolation and expression of human cytokine synthesis inhibitory factor cDNA clones: Homology to Epstein-Barr virus open reading frame BCRFI," PNAS, vol. 88, pp. 1172-1176, Feb. 1991.

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