Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Phosphoproteins – e.g. – phosvitin – vitellogenin – etc.
Patent
1995-06-06
1998-05-26
Woodward, Michael P.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Phosphoproteins, e.g., phosvitin, vitellogenin, etc.
530358, 530387, 53038873, 5303888, 5303891, 530828, 435 723, C07K 14435, C07K 1447, C07K 1618, G01N 33574
Patent
active
057566763
ABSTRACT:
Three mammalian are disclosed which are useful in the diagnosis and prognosis of tumors of lymphoid and epithelial origin. The three proteins are immunologically related to each other. The level of expression of the proteins correlates with the malignant potential of lymphoid and epithelial tumors. In addition, in some cases the subcellular location of the proteins is indicative of malignant potential. Antibodies reactive with the proteins are disclosed as diagnostic tools, as are nucleic acid probes and primers for quantitating the messenger RNAs encoding the proteins. Methods for preparing and purifying the proteins are also taught.
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Johns Hopkins University
Woodward Michael P.
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