Mammalian primate erythrocyte bound heteropolymerized monoclonal

Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Structurally-modified antibody – immunoglobulin – or fragment...

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4241421, 4241471, 4241501, 4241531, 435 7021, 4351722, 43524027, 5303873, 53038815, 5303883, 5303884, A61K 39395, A61K 3940, A61K 3942

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054878900

ABSTRACT:
Mammalian red blood cells are used to safely and rapidly neutralize and/or clear antigens or immunogens from the circulatory system by binding to the RBC a monoclonal antibody specific for a receptor (CR1) on the RBC, which monoclonal antibody is chemically bound to a second Mab specific for the antigen to be cleared from the circulatory system. These chemically cross-linked monoclonal antibody heteropolymers may be injected directly into the patient's circulatory system. Alternatively, red blood cells, extracted from the patient or provided by a suitable donor, are bound to the Mab complex and returned to the system.

REFERENCES:
patent: 4433059 (1984-02-01), Chang et al.
Edberg et al., "Quantitative Andyes Of The Binding Of Soluble Complement Fixing Antibody/dsDNA Immune Complexes To CR1 On Human Blood Cells" J. Immunol. 139(11):3739-3747, Dec. 1, 1987.
Titus et al., "Human K/Natural Killer Cells Targeted With Hetero-Cross-Linker Antibodies Specifically Lyse Tumor Cells In Vitro And Prevent Tumor Growth In Vivo," J. Immunol. 139(9):3153-3158, Nov. 1, 1987.
Karporsky et al, "Production Of Target Specific Effector Cells Using Hetero-Cross-Linked Aggregates Containing Anti-Target Cell and Anti-Fc.sub..lambda. Receptor Antibodies," J. Exp. Med. 160:1686-1701, Dec., 1984.
Taylor et al., "In Vivo Binding And Clearance Of Circulating Antigen By Bispecific Heteropolymer-Medical Binding To Primate Erythrocyte Complement Receptor," J. Immunol. 148(8):2462-2468, Apr. 15, 1992.
Kimberly et al., "In Vivo Handling Of Soluble Complement Fixing Ab/dsDNA Immune Complexes In Chimpanzees," J. Clin. Invest. 84:962-970, Sep. 1989.
Reist et al., "Antigens Pre-Bound To The Primate Erythrocyte Complement Receptor Via Cross-linked Bispecific Monoclonal Antibody Heteropolymers Are Rapidly Cleared From The Circulatory," Eur. J. Immunol. 23:3021-3027, 1993.

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