Mammalian opioid receptor ligand and uses

Details Mammalian opioid receptor ligand and uses Mammalian opioid receptor ligand and uses

1995-08-11

1998-11-17

Teng, Sally P.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

15 to 23 amino acid residues in defined sequence

530300, 530350, 435 691, C07K 708, C07K 14705

Patent

active

058378090

ABSTRACT:
The present invention relates to a novel mammalian opioid receptor protein and ligands that bind to such proteins. The invention is directed toward the isolation, characterization and pharmacological use of an endogenous ligand that specifically binds to a novel mammalian opioid receptor protein heterologously expressed in mammalian cells. The invention specifically provides the isolated peptide ligand and analogues, derivatives and variants thereof. The invention specifically provides tyrosine substitution variants of the peptide ligand that specifically bind to the opioid receptor and can be radioiodinated. Also provided are methods of making such peptide ligands and methods of using the ligands for diagnostic and therapeutic uses and for the identification of other naturally-occurring or synthetic opioid receptor ligands.

REFERENCES:
Zagon et al., Neuroscience Research, 3, 1-19, 1985.
Reinscheid et al., Science, 270, 792-794, 1995.
Meunier et al., Nature, 377, 532-535, 1995.
Saito et al., Biochem. and Biophys. Res. Commun., 217, 539-545, 1995.

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