Chemistry: molecular biology and microbiology – Treatment of micro-organisms or enzymes with electrical or... – Modification of viruses
Patent
1995-06-07
1998-12-15
LeGuyader, John I.
Chemistry: molecular biology and microbiology
Treatment of micro-organisms or enzymes with electrical or...
Modification of viruses
435 691, 4353201, 435325, 435353, C12N 1585, C12N 1509
Patent
active
058495533
ABSTRACT:
The invention includes mammalian multipotent neural stem cells and their progeny and methods for the isolation and clonal propagation of such cells. At the clonal level the stem cells are capable of self regeneration and asymmetrical division. Lineage restriction is demonstrated within developing clones which are sensitive to the local environment. The invention also includes such cells which are transfected with foreign nucleic acid, e.g., to produce an immortalized neural stem cell, and immortalized cell lines which are capable of subsequent disimmortalization. The invention further includes transplantation assays which allow for the identification of mammalian multipotent neural stem cells from various tissues and methods for transplanting mammalian neural stem cells and/or neural or glial progenitors into mammals. A novel method for detecting antibodies to neural cell surface markers is disclosed as well as a monoclonal antibody to mouse LNGFR.
REFERENCES:
patent: 4705751 (1987-11-01), Mosher
patent: 4707448 (1987-11-01), Major
patent: 5061620 (1991-10-01), Tsukamota et al.
patent: 5087570 (1992-02-01), Weissman et al.
Orkin et al. 1995 "Report and Recommendations of the Panel to assess the NIH Investment in Research on Gene Therapy".
Lo, L.-C., et al., "V-myc Immortalization of Early Rat Neural Crest Cells Yields a Clonal Cell Line Which Generates Both Glial and Adrenergic Progenitor Cells." Developmental Biology, 145:139-153 (1991).
Stemple, D.L., et al., "A Schwann Cell Antigen Recognized by Monoclonal Antibody 217c is the Rat Low-Affinity Nerve Growth Factor Receptor." Neuroscience Letters, 124:57-60 (1991).
Murphy, M., et al., "Generation of Sensory Neurons is Stimulated by Leukemia Inhibitory Factor." Proc. Natl. Acad. Sci. USA, 88:3498-3501 (1991).
Perris, R., et al., "Local Embryonic Matrices Determine Region-Specific Phenotypes in Neural Crest Cells." Science 241:86-89 (1988).
Morrison-Graham, K., et al., "Extracellular Matrix from Normal but Not Steel Mutant Mice Enhances Melanogenesis in Cultured Mouse Neural Crest Cells." Developmental Biology 139:299-307 (1990).
Boisseau, S., et al., "Mammalian Neuronal Differentiation: Early Expression of a Neuronal Phenotype from Mouse Neural Crest Cells in a Chemically Defined Culture Medium." Development 106:665-674 (1989).
Smith-Thomas, L.C., et al., "Expression of Schwann Cell Markers by Mammalian Neural Crest Cells in vitro" Development 105:251-262 (1989).
Deville, F.S.S.C., et al., "Developmental Potentialities of Cells Derived from the Truncal Neural Crest in Clonal Cultures." Developmental Brain Research 66:1-10 (1992).
Baroffio, A., et al., "Common Precursors for Neural and Mesectodermal Derivatives in the Cephalic Neural Crest." Development 112:301-305 (1991).
Baroffio, A., et al., "Clone-Forming Ability and Differentiation Potential of Migratory Neural Crest Cells." Proc. Natl. Acad. Sci. USA 85:5325-5329 (1988).
Dupin, E., et al., "Schwann-Cell Differentiation in Clonal Cultures of the Neural Crest, as Evidenced by the Anti-Schwann Cell Myelin Protein Monoclonal Antibody." Proc. Natl. Acad. Sci. USA 87:1119-1123 (1990).
Cohen, A.M., et al., "A Clonal Approach to the Problem of Neural Crest Determination." Developmental Biology 46:262-280 (1975).
Sieber-Blum, M., et al., "Clonal Analysis of Quail Neural Crest Cells: They Are Pluripotent and Differentiate in Vitro in the Absence of Noncrest Cells." Developmental Biology 80:96-106 (1980).
Duff, R.S., et al., "In Vitro Clonal Analysis of Progenitor Cell Patterns in Dorsal Root and Sympathetic Ganglia of the Quail Embryo." Developmental Biology 147:451-459 (1990).
Bronner-Fraser, M., et al., "Developmental bPotential of Avian Trunk Neural Crest Cells In Situ." Neuron 3:755-766 (1989).
Bronner-Fraser, M., et al., "Cell Lineage Analysis Reveals Multipotency of Some Avian Neural Crest Cells." Nature 355:161-164 (1988).
Fraser, S.E., et al., "Migrating Neural Crest Cells in the Trunk of the Avian Embryo are Multipotent." Development 112:913-920 (1991).
Frank, E., et al., "Lineage of Neurons and Glia in Chick Dorsal Root Ganglia: Analysis in vivo with a Recombinant Retrovirus." Development 111:895-907 (1991).
Le Douarin, N.M., "Cell Line Segregation During Peripheral Nervous System Ontogeny." Science 231:1515-1522 (1986).
Gorham, J.D., et al., "The Expression of the Neuronal Intermediate Filament Protein Peripherin in the Rat Embryo." Developmental Brain Research 57:235-248 (1990).
Portier, M.M., et al., "Regulation of Peripherin in Mouse Neuroblastoma and Rat PC 12 Pheochroomocytoma Cell Lines." Dev. Neurosci. 6:215-266 (1983/84).
Portier, M.M., et al., "Peripherin, a New Member of the Intermediate Filament Protein Family." Dev. Neurosci. 6:336-344 (1983/84).
Parysek, L.M., et al., "Distribution of a Novel 57 kDa Intermediate Filament (IF) Protein in the Nervous System." The Journal of Neuroscience 8:555:563 (1988).
Parysek, L.M., et al., "A Type III Intermediate Filament Gene Is Expressed in Mature Neurons." Neuron 1:395-401 (1988).
Anderson, D.J., et al., "A Biopotential Neuroendocrine Precursor Whose Choice of Cell Fate is Determined by NGF and Glucocorticoids." Cell 47:1079-1090 (1986).
Birren, S.J., et al., "A v-myc-Immortalized Sympathoadrenal Progenitor Cell Line in Which Neuronal Differentiation is Initiated by FGF but Not NGF." Neuron 4:189-201 (1990).
Potten, C.S., et al., "Stem Cells: Attributes, Cycles, Spirals, Pitfalls and Uncertainties Lessons for and From the Crypt." Development 110:1001-1020 (1990).
Hall, P.a., et al., "Stem Cells: The Generation and Maintenance of Cellular Diversity." Development 106:619-633 (1989).
Raff, M.C., et al., "A Glial Progenitor Cell that Develops in vitro into an Astrocyte or an Oligodendrocyte Depending on Culture Medium." Nature 303:390-396 (1983).
Jessen, K.R., et al., "Threee Markers of Adult Non-Myelin-Forming Schwann Cells, 217c(Ran-1), A5E3 and GFAP: Development and Regulation by Neuron-Schwann Cell Interactions." Development 109:91-103 (1990).
Reynolds, B.A., et al., "Generation of Neurons and Astrocytes from Isolated Cells of the Adult Mammalian Central Nervious System." Science 255:1707-1710 (1992).
Porter, S., et al., "Schwann Cells Stimulated to Proliferate in the Absence of Neurons Retain Full Functional Capability." The Journal of Neuroscience 6:3070-3078 (1986).
Brockes, J.P., et al., "Studies on Cultured Rat Schwann Cells. I. Establishment of Purified Populations from Cultures of Peripheral Nerve." Brain Research 165:105-118 (1979).
Huzar, D., et al., "Migration and Proliferation of Cultured Neural Crest Cells in W Mutant Neural Crest Chimeras." Development 112:131-141 (1991).
Anderson, D.J., "The Neural Crest Cell Lineage Problem: Neuropoiesis." Neuron 3:1-12 (1989).
Dodd, J., et al., "Spatial Regulation of Axonal Glycoprotein Expression on Subsets of Embryonic Spinal Neurons." Neuron 1:105-116 (1988).
Ross, A.H., et al., "Characterization of Nerve Growth Factor REceptor in Neural Crest Tumors Using Monoclonal Antibodies." Proc. Natl. Acad. Sci. USA 81:6681-6685 (1984).
Johnson, D., et al., "Expression and Structure of the Human NGF Receptor." Cell 47:545-554 (1986).
Chandler, C.E., et al., "A Monoclonal Antibody Modulates the Interaction Nerve Growth Factor with PC12 Cells." The Journal of Biological Chemistry 259:6882-6889 (1984).
Chao, M.V., et al., "Gene Transfer and Molecular Cloning of the Human NGF Receptor." Science 232:518-521 (1986).
Radeke, M.J., et al., "Gene Transfer and Molecular Cloning of the Rat Nerve Growth Factor Receptor." Nature 325:593-597 (1987).
Weskanp, G., et al., "Evidence that Biological Activity of NGF is Mediated through a Novel Subclass of High Affinity Receptors." Neuron 6:649-663 (1991).
Lendahl, U., et al., "CNS Stem Cells Express a New Class of Intermediate Filament Protein." Cell 60:585-595 (1990).
Hockfield, S., et al., "Identificateion of Major Cell Classes in teh Developing Mammalian Nervous System." The Journal of Neuroscience 5:3310-3328 (1985).
Friedman, B., et al., "Monoclonal Antibody Rat 401 Recognizes Schwann Cells in Mature and Developing Peripheral Nerve." The J
Anderson David J.
Stemple Derek L.
California Institute of Technology
LeGuyader John I.
Silva Robin M.
Trecartin Richard F.
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