Drug – bio-affecting and body treating compositions – Whole live micro-organism – cell – or virus containing – Virus or bacteriophage
Patent
1992-07-02
1996-04-30
Chambers, Jasemine C.
Drug, bio-affecting and body treating compositions
Whole live micro-organism, cell, or virus containing
Virus or bacteriophage
424 92, 4242081, 800 2, 800DIG5, A61K 4900, A01N 6300
Patent
active
055122817
ABSTRACT:
A mammalian model system for the pathogenesis of lentiviral, especially HIV-1, infection during fetal gestation is disclosed. The model system is used in methods of testing various regimens for prophylaxis of fetal lentiviral infection. In the model system, fetal infection is established in a pregnant mammal (e.g., a rhesus monkey, Macaca mulatta or a pigtailed macaque, Macaca nemestrina) by ultrasound guided inoculation of an inoculum of a lentivirus, e.g., SIV, into the amniotic fluid. The testing methods include the analysis of the effectiveness of potential immunotherapeutic and transplacental drug therapy regimens. The model will also allow testing which viral isolates are pathogenic to the developing fetus.
REFERENCES:
Oleske et al., "Immune Deficiency Med.Syndrome in Children," J. Am. Assoc. 249: 2345-2349 (1983).
Rubinstein et al., "Acquired Immunodeficiency With Reversed T.sub.4 /T.sub.8 Ratios in Infants Born to Promiscuous and Drug-Addicted Mothers," J. Am. Med. Assoc. 249: 2350-2356 (1983).
Scott et al., "Acquired Immunodeficiency Syndrome in Infants," N.E. J. Med. 310: 76-81 (1984).
Piot et al., "AIDS: Ani International Perspective," Science 239: 573-579 (1988).
Curran et al., "Epidemiology of HIV Infection and AIDS in the United States," Science 239: 610-616 (1988).
Ryder et al., "Perinatal Transmission of the Human Immunodeficiency Virus Type 1 to Infants of Seropositive Women in Zaire," N.E. J. Med. 320: 1637-1642 (1989).
Centers for Disease Control Morbid. Mortal. Weekly Rep. 40: 357-358 (1991).
Sharpe et al., "Retroviruses and Mouse Embryos: A Rapid Model for Neurovirulence and Transplacental Therapy," Science 236: 1671-1674 (1987).
Sharpe et al., "Maternal transmission of retroviral disease: Transgenic mice as a rapid test system for evaluating perinatal and transplacental antiretroviral therapy," Proc. Natl. Acad. Sci. USA 85: 9792-9796 (1988).
Sharpe et al., "Maternal Transmission of Retroviral Disease and Strategies for Preventing Infection of the Neonate," J. Virol. 63: 1049-1053 (1989).
London et al., "Experimental Congenital Disease with Simian Cytomegalovirus in Rhesus Monkeys," Teratology 33: 323-331 (1986).
London et al., "Congenital Cerebral and Ocular Malformations Induced in Rhesus Monkeys by Venezuelan Equine Encephalitis Virus," Teratology 16: 285-296 (1977).
London et al., "Teratological Effects of Western Equine Encephalitis Virus on the Fetal Nervous System of Macaca mulatta, " Teratology 25: 71-79 (1982).
London et al., "Induction of Congenital Hydrocephalus with Mumps Virus in Rhesus Monkeys," J. Inf. Diseases 139: 324-328 (1979).
Chakrabarti et al., "Sequence of simian immunodeficiency virus from macaque and its relationship to other human and simian retroviruses," Nature 328: 543-547 (1987).
Letvin et al., "Induction of AIDS-like Disease in Macaque Monkeys with T-Cell Tropic Retrovirus STLV-III," Science 230: 71-73 (1985).
Daniel et al., "Prevalence of Antibodies to 3 Retroviruses in a Captive Colony of Macaque Monkeys," Int. J. Cancer 41: 601-608 (1988).
Eichbert et al., "In Utero Infection of an Infant Chimpanzee with HIV," N.E. J. Med. 319: 722-723 (1988).
Jehuda-Cohen et al., "Presence of SIV Antibodies in the Sera of Infants Born to SIV-Seronegative Monkeys," J. AIDS 4: 204-205 (1991).
Nowak, "A New Primate Model For HIV-1 Infection," J. NIH Res. 4: 42 (1992).
Palca, "A Surprise Animal Model for AIDS," Science 256: 1630-1632 (1992).
Palca, "AIDS Vaccines: Chimps Protected From Infected Cells," Science 256: 1632 (1992).
Agy et al., "Infection of Macaca nemestrina by Human Immunodeficiency Virus Type-1," Science 257:103-106 (1992).
World Health Organization Meeting Report--Geneva, Sep. 14-15, 1989, "Biological S." 18:225-234.
Chambers Jasemine C.
Dana-Farber Cancer Institute Inc.
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