Mammalian model for diabetes

Details Mammalian model for diabetes Mammalian model for diabetes

2007-09-18

2007-09-18

Sullivan, Daniel M. (Department: 1636)

Multicellular living organisms and unmodified parts thereof and

Method of using a transgenic nonhuman animal in an in vivo...

C800S018000, C800S025000

Reexamination Certificate

active

10252111

ABSTRACT:
An object of the present invention is to provide a model mammal for diabetes onset, being useful for elucidating the onset mechanism of diabetes caused by a blockage of signal transduction from insulin, and for the development of a remedy for said diabetes, and to provide a screening method of a remedy for said diabetes. A diabetic-prone transgenic mouse is prepared in a process comprising the steps of: a transgene that contains a Meg1/Grb10 gene, an imprinted gene exhibiting maternal expression, or a human GRB10 gene in the downstream of a chicken β-actin promoter and in the upstream of a rabbit β-globin poly A is constructed, and subsequently the transgene is microinjected into a male proneucleus of a mouse fertilized egg; thus obtained egg cell is cultured and then transplanted into an oviduct of a pseudopregnant female mouse; after rearing up the recipient animal, baby mice that have the above-mentioned cDNA are selected from the mice born from the recipient animal.

REFERENCES:
patent: WO96/32087 (1996-10-01), None
patent: WO9637612 (1996-11-01), None
patent: WO 01/28321 (2001-04-01), None
Doetschman T. Interpertation of phenotype in genetically engineered mice. Lab Anim Sci. Apr. 1999;49(2):137-43.
Holschneider et al. Genotype to phenotype: challenges and opportunities. Int J Dev Neurosci. Oct. 2000;18(6):615-8.
Monk et al. Duplication of 7p11.2-p13, including GRB10, in Silver-Russell syndrome. Am J Hum Genet. Jan. 2000;66(1):36-46.
Yoshihashi et al. Imprinting of human GRB10 and its mutations in two patients with Russell-Silver syndrome. Am J Hum Genet. Aug. 2000;67(2):476-82. Epub Jun. 12, 2000.
Hitchins et al. Maternal repression of the human GRB10 gene in the developing central nervous system; evaluation of the role for GRB10 in Silver-Russell syndrome. Eur J Hum Genet. Feb. 2001;9(2):82-90.
Shiura et al. Meg1/Grb10 overexpression causes postnatal growth retardation and insulin resistance via negative modulation of the IGF1R and IR cascades. Biochem Biophys Res Commun. Apr. 15, 2005;329(3):909-16.
O'Neill et al. Interaction of a GRB-IR splice variant (a human GRB10 homolog) with the insulin and insulin-like growth factor I receptors. Evidence for a role in mitogenic signaling. J Biol Chem. Sep. 13, 1996;271(37):22506-13.
Sarani et al., “Nuclear Transplantation in the Mouse: Heritable Difference between Parental Genomes after Activation of the Embryonic Genome”,Cell, vol. 45, Apr. 1986, pp. 127-136.
McGrath et al., “Completion of Mouse Embryogenesis Requires Both the Maternal and Paternal Genomes”,Cell, vol. 37, May 1984, pp. 179-183.
DeChiara et al., “Parental Imprinting of the Mouse Insulin-like Growth Factor II Gene”,Cell, vol. 64, Feb. 22, 1991, pp. 849-859.
Cattanach et al., “Differential Activity of Maternally and Paternally Derived Chromosome Regions In Mice”,Nature, vol. 315, Jun. 6, 1985, pp. 496-498.
Cattanach et al., “Genomic Imprinting In The Mouse: Possible Final Analysis,” found in book entitledFrontiers in Molecular Biology, IRL Press, Oxford, 1997, pp. 118-145 (as well as a copy of the cover of the book and print information pages).
Reik, “Genomic Imprinting and Genetic Disorders in Man”,Trends Genet, vol. 5, No. 10, Oct. 1989, pp. 331-336.
Sapienza, “Genome Imprinting and Cancer Genetics”,Seminars in Cancer Biology, vol. 3, 1992, pp. 151-158.
Ledbetter et al., “Uniparental Disomy In Humans: Development of an Imprinting Map and Its Implications for Prenatal Diagnosis”,Human Molecular Genetics, vol. 4, 1995, pp. 1757-1764.
Hurst et al., “Growth Effects of Uniparental Disomies and the Conflict Theory of Genomic Imprinting”,Trends Genet, vol. 13, No. 11, Nov. 1997, pp. 436-443.
Ooi, et al., “The Cloning of Grb10 Reveals a New Family of SH2 Domain Proteins”,Oncogene, vol. 10, 1995, pp. 1621-1630.
Miyoshi et al., “Identification of theMegIIGrb10Imprinted Gene on Mouse Proximal Chromosome 11, A Candidate for the Silver-Russell Syndrome Gene”,Proc. Natl. Acad. Sci. USA, vol. 95, Feb. 1998, pp. 1102-1107.
Jerome et al., “Assignment of Growth Factor Receptor-Bound Protein 10 (GRB10) to Human Chromosome 7p11.2-p12”,Genomics, vol. 40, 1997, pp. 215-216.
Barton et al., “Manupulations of Genetic Constitution by Nuclear Transplantation”,Methods in Enzymology, vol. 225, 1993, pp. 732-744.
Kaneko-Ishino et al., “PegI/MestImprinted Gene on Chromosome 6 Identified By cDNA Substraction Hybridization”,Nature Genetics, vol. 11, Sep. 1995, pp. 52-59.
Niwa et al., “Efficient Selection for Hig-Expression Transfectants With a Novel Eukaryotic Vector”,Gene, vol. 108, 1991, pp. 193-200.
Shiratori et al., “Gene Therapy for Hepatic Micrometastasis of Murine Colon Carcinoma”,Journal of Hepatology, vol. 28, 1998, pp. 886-895.
Vollenweider—Insulin Resistant States and Insulin Signaling, Clin Chem Lab Med 2003; 41(9); 1107-1119.
Mattson, Bran Evolution and Lifespan Regulation; Conservation of Signal Transduction pathways that regulate energy metabolism, Mechanisms of Ageing and Development 123 (2002) 947-953.
Di Paola at., Association of hGrb 10 Genetic Variations with Type 2 Diabetes in Caucasian Subjects, Diabetes Care, vol. 29, No. 5, May 2006.
Tatar et al., The Endocrine Regulation of Aging by Insulin-like Signals, Feb. 28, 2003, vol. 299, Science, www.sciencemag.org.

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