Mammalian metallothionein promoter system

Details Mammalian metallothionein promoter system Mammalian metallothionein promoter system

1982-11-24

1986-07-22

Wiseman, Thomas G.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Enzymatic production of a protein or polypeptide

435 70, 435 91, 4351723, 435253, 435240, 435241, 435317, 536 27, 935 6, 935 32, 935 36, 935 70, C12N 120, C12N 500, C12N 502, C12N 100, C12N 1500, C12P 2100, C12P 2102, C12P 1934, C07H 2104

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active

046019782

ABSTRACT:
A cloning vector comprises a replication system from a bovine papilloma virus, a regulatory system including the promoter and terminator from a human metallothionein II gene, and a prokaryotic replication system. The vector is useful for transforming mammalian cells where it is maintained as an automonously replicating episome. Transcription may be regulated by the presence of heavy metals and/or glucocorticoid hormones in the growth media.

REFERENCES:
Karin et al., Nucleic Acids Res. 10, 3165 (1982).
Durnam et al., Proc. Natl. Acad. Sci. USA 77, 6511 (1980).
Pulido et al., Biochemistry 5, 1768 (1966).
Brinster et al., Nature 296, 39 (1982).
Hager et al., Nature 291, 340 (1981).
Karin, Diss. Abstr. 40(9), 4084 (1980).
Douglas R. Lowy, et al,. Nature (1980) 287:72-74.
Ming-Fan Law et al., Proc. Natl. Acad. Sci. USA (1981) 78:2727-2731.
Sarver et al., Preprint of Mol. Cell Biol. (1981).

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