Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1996-03-19
2000-10-24
Sisson, Bradley
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
435193, 435194, C07H 2104, C12N 910, C12N 912
Patent
active
061369640
ABSTRACT:
There is disclosed cDNA sequences and polypeptides having the enzyme lysophosphatidic acid acyltransferase (LPAAT) activity. LPAAT is also known as 1-acyl sn-glycerol-3-phosphate acyltransferase.
REFERENCES:
patent: 5563058 (1996-10-01), Davies et al.
patent: 5652243 (1997-07-01), Bianco et al.
Brough et al., Molecular Breeding, vol. 2, No. 2, p. 133-142, "Towards the genetic engineering of triacylglycerols of defined fatty acid composition: major changes in erucic acid content at the sn-2 position affected by the introduction of a 1-acyl-sn-glycerol-3-phosphate acyltransferase from Limnanthes douglasii into oil seed rape," 1996.
Coleman, Mol. Gen. Genet. vol. 232, p. 295-303, "Characterization of the Escherichia coli gene for 1-acyl-sn-glycerol-3-phosphate acyltransferase (plsC)," 1992.
Eberhardt et al., J. Biol. Chem. vol. 272, No. 32, p. 20299-20305, "Human Lysophosphatidic Acid Acyltransferase," 1997.
Kamisaka et al., J. Biochem., vol. 121, No. 6, p. 1107-1114, "Purification and Characterization of Diacylglycerol Acyltransferase from the Lipid Body Fraction of an Oleaginous Fungus," 1997.
Knutzon et al., Plant Phys., vol. 109, p. 999-1006, "Cloning of a Coconut Endosperm cDNA Encoding a 1-Acyl-sn-Glycerol-3-Phosphate Acyltransferase that Accepts Medium-Chain-Length Substrates," 1995.
Stamps et al., Biochem. J., vol. 326, p. 455-461, "A human cDNA sequence with homology to non-mammalian lysophosphatidic acid acyltransferases," 1997.
International Search Report Nov. 19, 1997.
Brown et. al., Plant Molecular Biology, vol. 26: 211-223 (1994), "Isolation and characterization of a maize cDNA that complements a 1-acyl sn-glyerol-3-phosphate acyltransferase mutant of Escherichia coli and encodes a protein which has similarities to other acyltransferases".
Brown et al., Plant Molecular Biology, vol. 29: 267-278 (1995), "Identification of a cDNA that encodes a 1-acyl-sn-glycerol-3-phosphate acyltransferase from Limnanthes douglasii".
Coleman, Mol Gen Genet, vol. 232: 295-303 (1992), "Characterization of the Escherichia coli gene for 1-acyl-sn-glycerol-3-phosphate acyltransferase (plsC)".
Hanke et al., Eur. J. Biochem, vol. 232: 806-810 (1995), "A plant acyltransferase involved in triacylglycerol biosynthesis complements as Escherichia coli sn-1-acylglycerol-3-phosphate acyltransferase mutant".
Knutzon et al., Plant Physiol, vol. 109: 999-1006 (1995), "Cloning of a Coconut Endosperm cDNA Encoding a 1-Acyl-sn-Glycerol-3-Phosphate Acyltransferase That Accepts Medium-Chain-Length Substrates".
Lassner et al., Plant Physiol., vol. 109: 1389-1394 (1995), "Lysophosphatidic Acid Acyltransferase from Meadowfoam Mediates Insertion of Erucic Acid at the sn-2 Position of Triacylglycerol in Transgenic Rapeseed Oil".
Nagiec et al., The Journal of Biological Chemistry, vol. 268(29): 22156-22163 (1993), "A Suppressor Gene That Enables Saccharomyces cerevisiae to Grow without Making Sphingolipids Encodes a Protein That Resembles an Escherichia coli Fatty Acyltransferase".
Swartley et al., Molecular Microbiology, vol. 18(3): 401-412 (1995), "Membrane glycerophospholipid biosynthesis in Neisseria meningitidis and Neisseria gonorrhoeae: identification, characterization and mutagenesis of a lysophosphatidic acid acyltransferase".
Sigma Catalog 1995, Sigma Chemical Company, St. Louis, Missouri. Pp. 320, 322, 323 and 327, Jan. 1995.
Leung David W.
Tompkins Christopher K.
West James W.
Cell Therapeutics Inc.
Faciszewski Stephen
Friedman Susan J.
Sisson Bradley
Stole Einar
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