Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving viable micro-organism
Patent
1995-06-05
1997-09-23
Fitzgerald, David L.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving viable micro-organism
536 235, 4353201, 4352402, 4352523, 43525411, 435 691, 435 721, 435 4, 530350, C12N 1512, C07K 14705
Patent
active
056703350
ABSTRACT:
This disclosure relates to two separate and distinct inward rectifier K.sup.+ channel expression products and the the genes which encode each expression product. The IRK1 gene (SEQ ID NO:1) encodes an inward rectifier K.sup.+ channel and the GIRK1 gene (SEQ ID NO:3) encodes a G protein coupled muscarinic K.sup.+ channel. The disclosure relates to the uses of these expression products, particularly in combination with identifying physiological processes mediated by these channels, such as regulation of heartbeat and insulin release and materials modulating or blocking same.
REFERENCES:
patent: 5492825 (1996-02-01), Jan et al.
Breitwieser, G. E., et al., "Uncoupling of cardiac muscarinic and .beta.-adrenergic receptors from ion channels by a guanine nucleotide analogue", Nature 317:538-540 (1985).
Logothetis, D. E., et al., "The .beta..gamma. subunits of GTP-binding proteins activate the muscarinic K.sup.+ channel in heart", Nature 325(6102):321-326 (1987).
Yatani, A., et al., "The G protein-gated atrial K.sup.+ channel is stimulated by three distinct G.sub.i .alpha.-subunits", Nature 336:680-682 (1988).
Brown, A. M., et al., "Ionic Channels and Their Regulation by G Protein Subunits", Annu. Rev. Physiol. 52:197-213 (1990).
Kurachi, Y., et al., "G Protein Activation of Cardiac Muscarinic K.sup.+ Channels", Progress in Neurobiology 39:229-246 (1992).
Nelson, M. T , et al., "Arterial dilations in response to calcitonin gene-related peptide involve activation of K.sup.+ channels", Nature 344:770-773 (1990).
Rorsman, P., et al., "Activation by adrenaline of a low-conductance G protein-dependent K.sup.+ channel in mouse pancreatic B cells", Nature 349:77-79 (1991).
Stanfield, P. R., et al., "Substance P raises neuronal membrane excitability by reducing inward rectification", Nature 315:498-501 (1985).
Williams, J. T., et al., "Voltage- and Ligand-Activated Inwardly Rectifying Currents in Dorsal Raphe Neurons in vitro", The Journal of Neuroscience 8(9):3499-3506 (1988).
Wang, W., et al., "Renal Potassium Channels and Their Regulation", Annu Rev. Physiol. 54:81-96 (1992).
Papazian, D. M., et al., "Cloning of Genomic and Complementary DNA from Shaker, a Putative Potassium Channel Gene from Drosophila", Science 237:749-753 (1987).
Tempel, B. L., et al. , "Sequence of a Probable Potassium Channel Component Encoded at Shaker Locus of Drosophila", Science 237:770-775 (1987).
Baumann, A., et al., "Molecular organization of the maternal effect region of the Shaker complex of Drosophila: characterization of an I.sub.A channel transcript with homology to vertebrate Na.sup.+ channel", The EMBO Journal 6(11):3419-3429 (1987).
Wei, A., et al., "K.sup.+ Current Diversity Is Produced by an Extended Gene Family Conserved in Drosophila and Mouse", Science 248:599-603 (1990).
Tempel, B. L., et al., "Cloning of a probable potassium channel gene from mouse brain", Nature 332:837-839 (1988).
Baumann, A., et al., "Structure of the voltage-dependent potassium channel is highly conserved from Drosophila to vertebrate central nervous systems", The EMBO Journal 7(8):2457-2463 (1988).
Frech, G. C., et al., "A novel potassium channel with delayed rectifier properties isolated from rat brain by expression cloning", Nature 340:642-645 (1989).
Yokoyama, S., et al., "Potassium channels from NG108-15 neuroblastoma-glioma hybrid cells", FEBS Letters 259(1):37-42 (1989).
Christie, M. J., et al., "Expression of a Cloned Rat Brain Potassium Channel in Xenopus Oocytes", Science 244:221-224 (1989).
Stuhmer, W., et al., "Molecular basis of functional diversity of voltage-gated potassium channels in mammalian brain", The EMBO Journal 8(11):3235-3244 (1989).
Swanson, R., et al., "Cloning and Expression of cDNA and Genomic Clones Encoding Three Delayed Rectifier Potassium Channels in Rat Brain", Neuron 4:929-939 (1990).
Luneau, C. J., et al., "Alternative splicing contributes to K.sup.+ channel diversity in the mammalian central nervous system", Proc. Natl. Acad. Sci. USA 88:3932-3936 (1991).
Jan, L. Y., et al., "Tracing the Roots of Ion Channels", Cell 69:715-718 (1992).
Jan, L. Y., et al., "A superfamily of ion channels", Nature 345:672 (1990).
Takumi, T., et al., "Cloning of a Membrane Protein That Induces a Slow Voltage-Gated Potassium Current", Science 242:1042-1045 (1988).
Ho, K., et al., "Cloning and expression of an inwardly rectifying ATP-regulated potassium channel", Nature 362:31-38 (1993).
Katz, B., "Les Constantes Electriques De La Membrane Du Muscle", Archives Des Sciences Physiologiques III(2):285-300 (1949).
Standen, N. B., et al., "A Potential- and Time-Dependent Blockade of Inward Rectification in Frog Skeletal Muscle Fibres by Barium and Strontium Ions", J. Physiol. 280:169-191 (1978).
Sakmann, B., et al., "Conductance Properties of Single Inwardly Rectifying Potassium Channels in Ventricular Cells from Guinea-Pig Heart", J. Physiol. 347:641-657 (1984).
Hagiwara, S., et al., "Potassium Current and the Effect of Cesium on this Current during Anomalous Rectification of the Egg Cell Membrane of a Starfish", The Journal of General Physiology 67:621-638 (1976).
Okamoto, H., et al., "Membrane Currents of the Tunicate Egg under the Voltage-Clamp Condition", J. Physiol. 254:607-638 (1976).
Mayer, M. L., et al., "A Voltage-Clamp Analysis of Inward (Anomalous) Rectification in Mouse Spinal Sensory Ganglion Neurones", J. Physiol. 340:19-45 (1983).
Mihara, S., et al., "Somatostatin Increases an Inwardly Rectifying Potassium Conductance in Guinea-Pig Submucous Plexus Neurones", J. Physiol. 390:335-355 (1987).
Inoue, M., et al., "Somatostatin Induces an Inward Rectification in Rat Locus Coeruleus Neurones Through a Pertussis Toxin-Sensitive Mechanism", Journal of Physiology 407:177-198 (1988).
Barres, B. A., "Glial ion channels", Neurobiology 1:354-359 (1991).
McKinney, L. C., et al., "Inwardly Rectifying Whole-Cell and Single-Channel K Currents in the Murine Macrophage Cell Line J774.1", J. Membrane Biol. 103 41-53 (1988).
Lewis, D. L., et al., "Expression of an inwardly rectifying K.sup.+ channel rat basophilic leukemia cell mRNA in Xenopus oocytes", FEBS Letters 290(1.2):17-21 (1991).
Silver, M. R., et al., "Intrinsic Gating of Inward Rectifier in Bovine Pulmonary Artery Endothelial Cells in the Presence or Absence of Internal Mg.sup.2+ ", Gen. Physiol. 96:109-133 (1990).
Hagiwara, S., et al., "Electrical Properties of Egg Cell Membranes", Ann. Rev. Biophys. Bioeng. 8:385-416 (1979).
Noma, A., et al., "Acetylcholine-Induced Potassium Current Fluctuations in the Rabbit Sino-Atrial Node", Pflugers Arch. 381:255-262 (1979).
Matsuda, H., et al., "Ohmic conductance through the inwardly rectifying K channel and blocking by internal Mg.sup.2+ ", Nature 325:157-159 (1987).
Vandenberg, C. A., "Inward rectification of a potassium channel in cardiac ventricular cells depends on internal magnesium ions", Proc. Natl. Acad. Sci. USA 84:2560-2564 (1987).
Matsuda, H., "Open-State Substructure of Inwardly Rectifying Potassium Channels Revealed by Magnesium Block in Guinea-Pig Heart Cells", Journal of Physiology 397:237-258 (1988).
Hagiwara, S., et al., "Anomalous Permeabilities of the Egg Cell Membrane of a Starfish in K.sup.+ -T1.sup.+ Mixtures", The Journal of General Physiology 70:269-281 (1977).
Ohmori, H., "Dual Effects of K Ions upon the Inactivation of the Anomalous Rectifier of the Tunicate Egg Cell Membrane", J. Membrane Biol. 53:143-156 (1980).
Trautwein, W., et al., "Zum Mechanismus der Membranwirkung des Acetylcholin an der Herzmuskelfaser", Pflugers Archiv. Bd. 266:324-334 (1958).
Sakmann, B., et al., "Acetylcholine activation of single muscarinic K.sup.+ channels in isolated pacemaker cells of the mammalian heart", Nature 303:250-253 (1983).
Soejima, M., et al., "Mode of regulation of the ACh-sensitive K-channel by the muscarinic receptor in rabbit atrial cells", Pfluger Arch. 400:424-431 (1984).
Yatani, A., et al., "Direct Activation of Mammalian Atrial Muscarinic Potassium Channels by GTP Regulatory Protein G.sub.k ", Science 235:207-211 (1987).
Kubo, Y., et al., "Primary structure and functional expression of a mouse
Jan Lily Y.
Jan Yuh Nung
Kubo Yoshihiro
Reuveny Eithan
Slesinger Paul A.
Fitzgerald David L.
The Regents of the University of California
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