Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1995-04-19
1998-02-10
Ulm, John
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
4352523, 4353201, 435 6, 435 71, 530350, 536 235, C07K 14705, C12N 1512
Patent
active
057168040
ABSTRACT:
Amino acid sequence and nucleic acid encoding various functional variants of the IL-10 receptors. Uses of the receptor gene and polypeptides are disclosed, including means for screening for agonists and antagonists of the receptor ligands, for producing diagnostic or therapeutic reagents, and for producing antibodies. Therapeutic or diagnostic reagents and kits are also provided.
REFERENCES:
J. Fernando Bazan "Structural design and molecular evolution of a cytokine receptor superfamily," Proc. Natl. Acad. Sci. 87:6934-6938, Sep. 1990.
J. Fernando Bazan "Haematopoietic receptors and helical cytokines," Immunol. Today 11:350-354, 1990.
Alan D. D'Andrea, et al. "The Cytoplasmic Region of the Erythropoietin Receptor Contains Nonoverlapping Positive and Negative Growth-Regulatory Domains," Molec. Cell. Biol. 11:1980-1987, Apr. 1991.
Rene de Waal Malefyt, et al. "Interleukin 10 (IL-10) Inhibits Cytokine Synthesis by Human Monocytes: An Autoregulatory Role of IL-10 Produced by Monocytes," J. Exp. Med. 174:1209-1220, Nov. 1991.
David F. Fiorentino, et al. "Two Types of Mouse Helper Cell," J. Exp. Med. 170:2081-2095, Dec. 1989.
David F. Fiorentino, et al. "IL-10 Inhibits Cytokine Production by Activated Macrophages," J. Immunol. 147:3815-3822, Dec. 1991.
David P. Gearing, et al. "Expression cloning of a receptor for human granulocyte-macrophage colony-stimulating factor," EMBO J. 8:3667-3676, 1989.
Kazuniro Hayashida, et al. "Molecular cloning of a second subunit of the receptor for human granulocyte-macrophage colony-stimulating factor (GM-CSF): Reconstitution of a high-affinity GM-CSF receptor," Proc. Natl. Acad. Sci. 87:9655-9659, Dec. 1990.
Alice Suk Yue Ho, et al. "A receptor for interleukin 10 is related to interferon receptors," Proc. Natl. Acad. Sci. 90:11267-11271, Dec. 1993.
Alice Suk Yue Ho, et al. "Interleukin-10 and its receptor," Ther. Immunol. 1:173-185, 1994.
Alice S.Y. Ho, et al. "Structural and Functional Studies of Interleukin-10 Receptors," Abstract #4315 from the American Association of Immunology Meeting, Apr. 1994.
Di-Hwei Hsu, et al. "Expression of Interleukin-10 Activity by Epstein-Barr Virus Protein BCRF1," Science 250:830-832, Nov. 1990.
Di-Hwei Hsu, et al. "Defferential effects of IL-4 and IL-10 on IL-2-induced IFN-.gamma. synthesis and lymphokine-activated killer activity," Intl. Immunol. 4:563-569, 1992.
Naoto Itoh, et al. "Cloning of an Interleukin-3 Receptor Gene: A Member of a Distinct Receptor Gene Family," Science 247:324-327, Jan. 1990.
Atsushi Miyajima, et al. "Common subunits of cytokine receptors and the functional redundancy of cytokines," TIBS 17:378-382, Oct. 1992.
Andrew C. Larner, et al. "Tyrosine Phosphorylation of DNA Binding Proteins by Multiple Cytokines," Science 261:1730-1733, Sep. 1993.
Jorg Lehmann, et al. "IL-10-Induced Factors Belonging to the p91 Family of Proteins Bind to IFN-.gamma.-Responsive Promoter Elements," J. Immunol. 165-172, 1994.
Ying Liu, et al. "Expression Cloning and Characterization of a Human IL-10 Receptor," J. Immunol. 152:1821-1829, 1994.
Atsushi Miyajima, et al. "Cytokine Receptors and Signal Transduction," Ann. Rev. Immunol. 10:295-331, 1992.
Kevin W. Moore, et al. "Homology of Cytokine Synthesis Inhibitory Factor (IL-10) to the Epstein-Barr Virus Gene BCRF1," Science 248:1230-1234, Jun. 1990.
Kevin W. Moore, et al. "Interleukin-10," Ann. Rev. Immunol. 11:165-190, 1993.
Tim R. Mosmann, et al. "The role of IL-10 in crossregulation of T.sub.H 1 and T.sub.H 2 responses," Immunol. Today 12:A49-A53, 1991.
Hans-Jurgen Rode, et al. "The Genome of Equine Herpesvirus Type 2 Harbors an Interleukin 10 (IL-10)-Like Gene," Virus Genes 7:111-116, 1993.
Kazuhiro Sakamaki, et al. "Critical cytoplasmic domains of the common .beta. subunit of the human GM-CSF, IL-3 and IL-5 receptors for growth signal transduction and tyrosine phosphorylation," EMBO J. 111:3541-3549, 1992.
Noriko Sato, et al. "Signal transduction by the high-affinity GM-SCF receptor: two distinct cytoplasmic regions of the common .beta. subunit responsible for different signaling," EMBO J. 12:4181-4189, 1993.
Jimmy C. Tan, et al. "Characterization of Interleukin-10 Receptors on Human and Mouse Cells," J. Biol. Chem. 268:21053-21059, Oct. 1993.
Jan Tavernier, et al. "A Human High Affinity Interleukin-5 Receptor (IL5R) Is Composed of an IL5-Specific .alpha. Chain and a .beta. Chain Shared with the Receptors for GM-CSF," Cell 66:1175-1184, Sep. 1991.
P. Vieira, et al. "Isolation and expressioin of human cytokine synthesis inhibitory factor cDNA clones: Homology to Epstein-Barr virus open reading frame BCRF1," Proc. Natl. Acad. Sci. 88:1172-1176, Feb. 1991.
Ho Alice Suk-Yue
Moore Kevin W.
Wei Sherry
Ching Edwin P.
Mohan-Peterson Sheela
Schering Corporation
Ulm John
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