Mammalian grainyhead transcription factors

Details Mammalian grainyhead transcription factors Mammalian grainyhead transcription factors

2003-08-08

2008-08-05

Guzo, David (Department: 1636)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C435S006120

Reexamination Certificate

active

07408048

ABSTRACT:
The present invention provides mammalian homologs of theDrosophilaGrainyhead (GRH) transcription factor, call MGR and means of identifying such proteins and their genes. Nucleic acid and protein sequences are provided for human and mouse MGR transcription factors. In addition mammalian isoforms of MGR including human MGR p49, human p70, mouse p70, mouse MGR p61, and human and mouse homologs of MGR, brother of mgr (BOM) and sister of mgr (SOM), are disclosed. Antibodies to and methods of using these identified MGR, BOM and SOM transcription factors are also provided. The present invention further provides medical assessment systems including drug evaluation systems comprising genetically modified animals.

REFERENCES:
patent: 1 074 617 (2001-02-01), None
patent: WO 00/58473 (2000-10-01), None
patent: WO 01/75067 (2001-10-01), None
patent: WO 02/30268 (2002-04-01), None
patent: WO 02/070539 (2002-09-01), None
patent: WO 02/071928 (2002-09-01), None
patent: WO 03/006618 (2003-01-01), None
GenBank Entry AY231160, pp. 1-2.
GenBank Entry BM460207, pp. 1-2.
Wilanowski, T et al. “Four new members of a highly conserved family of transcription factors related to Dorsophila gainyhead,” Development Growth and Differentiation (2001) 43: S87 (XP002376497).
Database EMBL cDNA FLJ23806 fis, clone HRC03576Homo sapiens(2002) (XP002376500).
Database EMBL CDNA FLJ23806 fis, clone HRC03576Homo sapiens(2002) (XP002376501).
European Search Report, Application No. EP 03 78 3841.
DGENE Abstract Accession No. AAG67096, CN 1303939 (Shanghai Borong Gene Dev. Co. Ltd.) Jul. 18, 2001.
Tomasz Wilanowski et al.,A Highly Conserved Novel Family Of Mammalian Developmental Transcription Factors Related To Drosophila grainyhead, Mechanisms of Development 114 (1-2) (2002) 37-50; GenBank Accession No. AF411210, AF411211, AF411212, AF411213, XP—018275 & XP—002272.
Genbank Accession No. AF411210.
Genbank Accession No. AF411211.
Genbank Accession No. AF411212.
Genbank Accession No. AF411213.
Genbank Accession No. XP—018276.
Genbank Accession No. XP—002272.
Stephen B. Ting, et al.The Identification And Characterization of Human Sister-of- Mammalian grainyhead(SOM)Expands The grainyhead-like Family of Developmental Transcription Factors, Biochem. J. (2003) 370 (Pt. 3), 953-962 (Printed in Great Britain); GenBank Accession No. AY231160, AY231161.
Genbank Accession No. AY231160.
Genbank Accession No. AY231161.
Ningwu Huang, et al.,Cloning of Factors Related to HIV-inducible LBP Proteins That Regulate Steroidogenic Factor-1-independent Human Placental Transcription of the Cholesterol Side-chain Cleavage Enzyme, P450ssc, The Journal of Biological Chemistry, vol. 275, No. 4, Jan. 28, 2000, pp. 2852-2858 (Printed in USA); GenBank Accession No. AF198489 & GenPept database Accession No. AAF32276.
Genbank Accession No. AF198489.
Genbank Accession No. AAF32276.
PCT International Search Report, Melbourne Health et al., PCT/AU03/01006, dated Sep. 19, 2003.
Strausberg R L et al., (2002) Proc. Natl. Acad. Sci USA 99(26): 16899-16903,Generation And Initial Analysis of More Than 15,000 Full-length Human And Mouse cDNA Sequences; GenBank Accession No. BC013080, BC036890, BC037233, BC042575, BC055035.
Genbank Accession No. BC013080.
Genbank Accession No. BC036890.
Genbank Accession No. BC037233.
Genbank Accession No. BC042575.
Genbank Accession No. BC055035.

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