Mammalian glomerular epithelial protein 1

Details Mammalian glomerular epithelial protein 1 Mammalian glomerular epithelial protein 1

1994-02-25

1998-01-06

Wax, Robert A.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

435196, C07H 2104, C12N 916

Patent

active

057056234

ABSTRACT:
This invention provides mammalian GLEPP1 proteins, which are expressed primarily on glomerular podocytes. The invention also provides DNA sequences encoding mammalian GLEPP1 proteins and PTPase domains of mammalian GLEPP1 proteins. The invention further provides methods of detecting and treating a glomerular pathology characterized by abnormally low GLEPP1 expression or abnormal distribution of GLEPP1 protein on a cell.

REFERENCES:
Thomas et al., "Molecular cloning of a glomerular epithelial cell specific membrane protein cDNA." FASEB J 5:A907 (1991).
Thomas et al., "Cloning and characterization of a glomerular epithelial cell specific protein (GLEPP1). " J. of Am. Society of Nephrology 2:566 (1991).
Schrier and Gottschalk, "Biochemical, structural, and functional correlations in the kidney." Diseases of the Kidney, 1:14-15 (1993).
Wiggins et al., "GLEPP1 is a multimeric podocyte membrane protein with a developmental pattern similar to that of podocalyxin." J. of Am. Society of Nephrology 3:622 (1992).
Thomas et al., "GLEPP1 is a podocyte specific transmembrane protein with a cytosolic protein tyrosine phosphatase domain." FASEB J 7:A214 (1993).
Wiggins et al., "GLEPP1 is a glomerular epithelial cell-specific transmembrane protein with a cytosolic protein tyrosine phosphatase domain." Kidney International (Jan., 1994).
Wiggins et al., "GLEPP1, a podocyte specific membrane protein tyrosine phosphatase from rabbit and man." Clinical Research Meeting (Apr., 1994).
Thomas et al. (1994) J. Biol. Chem. 269(31): 1953-19962.

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